Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1015134..1015635 Replicon chromosome
Accession NZ_CP085086
Organism Streptococcus suis strain Ssuis_MA6

Toxin (Protein)


Gene name relE Uniprot ID A0A0M9FF45
Locus tag LIO31_RS05160 Protein ID WP_024405694.1
Coordinates 1015134..1015400 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag LIO31_RS05165 Protein ID WP_012775104.1
Coordinates 1015384..1015635 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO31_RS05135 1010363..1010599 + 237 WP_226319150.1 hypothetical protein -
LIO31_RS05140 1010766..1011836 + 1071 WP_024405698.1 tyrosine recombinase XerS -
LIO31_RS05145 1011906..1013414 - 1509 WP_024405697.1 phosphoglucomutase -
LIO31_RS05150 1013489..1014430 - 942 WP_024405696.1 sensor histidine kinase -
LIO31_RS05155 1014427..1015092 - 666 WP_024405695.1 response regulator transcription factor -
LIO31_RS05160 1015134..1015400 - 267 WP_024405694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO31_RS05165 1015384..1015635 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
LIO31_RS05170 1015727..1017697 - 1971 WP_074389880.1 FtsX-like permease family protein -
LIO31_RS05175 1017698..1018450 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
LIO31_RS05180 1018471..1018848 - 378 WP_011922413.1 NisI/SpaI family lantibiotic immunity lipoprotein -
LIO31_RS05185 1018861..1019001 - 141 WP_012775106.1 hypothetical protein -
LIO31_RS05190 1019141..1020307 - 1167 WP_011922414.1 carbamoyl phosphate synthase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10392.08 Da        Isoelectric Point: 10.6122

>T220426 WP_024405694.1 NZ_CP085086:c1015400-1015134 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T220426 NZ_CP117020:c1921790-1921479 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT220426 WP_012775104.1 NZ_CP085086:c1015635-1015384 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp

>AT220426 NZ_CP117020:c1921482-1921063 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M9FF45

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References