Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 769220..769706 Replicon chromosome
Accession NZ_CP085086
Organism Streptococcus suis strain Ssuis_MA6

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag LIO31_RS03990 Protein ID WP_011922754.1
Coordinates 769437..769706 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag LIO31_RS03985 Protein ID WP_002938604.1
Coordinates 769220..769447 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO31_RS03960 764553..765098 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
LIO31_RS03965 765161..765610 - 450 WP_024383028.1 MarR family transcriptional regulator -
LIO31_RS03970 765912..766409 + 498 WP_024405519.1 DUF5590 domain-containing protein -
LIO31_RS03975 766406..767587 + 1182 WP_024383693.1 pyridoxal phosphate-dependent aminotransferase -
LIO31_RS03980 767602..768948 + 1347 WP_024405517.1 asparagine--tRNA ligase -
LIO31_RS03985 769220..769447 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
LIO31_RS03990 769437..769706 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO31_RS03995 770112..771436 + 1325 Protein_754 MATE family efflux transporter -
LIO31_RS04000 771620..771997 + 378 WP_002937263.1 RidA family protein -
LIO31_RS04005 772019..772906 + 888 WP_002937261.1 RNase adapter RapZ -
LIO31_RS04010 772903..773877 + 975 WP_024383695.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T220425 WP_011922754.1 NZ_CP085086:769437-769706 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T220425 NZ_CP117020:c1207155-1206904 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT220425 WP_002938604.1 NZ_CP085086:769220-769447 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT220425 NZ_CP117020:c1206907-1206653 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References