Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 759951..761203 Replicon chromosome
Accession NZ_CP085086
Organism Streptococcus suis strain Ssuis_MA6

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag LIO31_RS03935 Protein ID WP_024405541.1
Coordinates 760427..761203 (+) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag LIO31_RS03930 Protein ID WP_024405542.1
Coordinates 759951..760427 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO31_RS03910 758597..759028 + 432 Protein_737 peptidylprolyl isomerase -
LIO31_RS03915 759067..759471 + 405 Protein_738 DNA primase -
LIO31_RS03920 759473..759541 + 69 Protein_739 DUF5945 family protein -
LIO31_RS03925 759591..759881 + 291 WP_024405543.1 hypothetical protein -
LIO31_RS03930 759951..760427 + 477 WP_024405542.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
LIO31_RS03935 760427..761203 + 777 WP_024405541.1 type II toxin-antitoxin system toxin PezT Toxin
LIO31_RS03940 761200..762099 + 900 WP_216092534.1 AAA family ATPase -
LIO31_RS03945 762203..762391 + 189 Protein_744 nuclear transport factor 2 family protein -
LIO31_RS03950 762404..763054 + 651 WP_216092535.1 SAP domain-containing protein -
LIO31_RS03955 763344..764456 + 1113 WP_024405520.1 UDP-galactopyranose mutase -
LIO31_RS03960 764553..765098 - 546 WP_002941732.1 NADPH-dependent FMN reductase -
LIO31_RS03965 765161..765610 - 450 WP_024383028.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 681700..768144 86444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29222.90 Da        Isoelectric Point: 5.6995

>T220424 WP_024405541.1 NZ_CP085086:760427-761203 [Streptococcus suis]
MRLEEFSEEEFQKALQRTIRAQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Download         Length: 777 bp

>T220424 NZ_CP117020:c1206907-1206653 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18303.70 Da        Isoelectric Point: 4.3241

>AT220424 WP_024405542.1 NZ_CP085086:759951-760427 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHWVVA

Download         Length: 477 bp

>AT220424 NZ_CP117020:c1207155-1206904 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References