Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 558114..558597 Replicon chromosome
Accession NZ_CP085086
Organism Streptococcus suis strain Ssuis_MA6

Toxin (Protein)


Gene name relE Uniprot ID D5AIX4
Locus tag LIO31_RS02880 Protein ID WP_012027435.1
Coordinates 558337..558597 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag LIO31_RS02875 Protein ID WP_012775256.1
Coordinates 558114..558335 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO31_RS02850 553868..554518 - 651 WP_023370907.1 HAD family hydrolase -
LIO31_RS02855 554626..555753 + 1128 WP_024406009.1 glycerate kinase -
LIO31_RS02860 555744..555971 + 228 WP_024406008.1 hypothetical protein -
LIO31_RS02865 555981..556433 - 453 WP_012028381.1 DUF1694 domain-containing protein -
LIO31_RS02870 556583..557890 + 1308 WP_002935704.1 phosphopyruvate hydratase -
LIO31_RS02875 558114..558335 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
LIO31_RS02880 558337..558597 + 261 WP_012027435.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO31_RS02885 558764..559405 + 642 WP_023370899.1 HAD family hydrolase -
LIO31_RS02890 559438..559623 - 186 WP_002935693.1 hypothetical protein -
LIO31_RS02895 559687..560691 - 1005 WP_023370897.1 lactonase family protein -
LIO31_RS02900 560827..561993 + 1167 WP_012775254.1 AI-2E family transporter -
LIO31_RS02905 561983..563212 + 1230 WP_226960924.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10273.79 Da        Isoelectric Point: 9.3944

>T220423 WP_012027435.1 NZ_CP085086:558337-558597 [Streptococcus suis]
MYHLEYSKKAQKQIMKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T220423 NZ_CP117020:c963018-962915 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT220423 WP_012775256.1 NZ_CP085086:558114-558335 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT220423 NZ_CP117020:962877-963148 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGCCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K1T1M7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References