220421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1451048..1451531 Replicon chromosome
Accession NZ_CP085085
Organism Streptococcus suis strain Ssuis_MA8

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag LIO34_RS07275 Protein ID WP_009910443.1
Coordinates 1451048..1451308 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag LIO34_RS07280 Protein ID WP_012775256.1
Coordinates 1451310..1451531 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO34_RS07250 1446433..1447662 - 1230 WP_009910437.1 tetratricopeptide repeat protein -
LIO34_RS07255 1447652..1448818 - 1167 WP_002935690.1 AI-2E family transporter -
LIO34_RS07260 1448954..1449958 + 1005 WP_009910438.1 lactonase family protein -
LIO34_RS07265 1450022..1450207 + 186 WP_002935693.1 hypothetical protein -
LIO34_RS07270 1450240..1450881 - 642 WP_002935700.1 HAD family hydrolase -
LIO34_RS07275 1451048..1451308 - 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO34_RS07280 1451310..1451531 - 222 WP_012775256.1 DUF6290 family protein Antitoxin
LIO34_RS07285 1451841..1453148 - 1308 WP_002935704.1 phosphopyruvate hydratase -
LIO34_RS07290 1453298..1453750 + 453 WP_013730449.1 DUF1694 domain-containing protein -
LIO34_RS07295 1453760..1453987 - 228 WP_002935708.1 hypothetical protein -
LIO34_RS07300 1453978..1455105 - 1128 WP_002935718.1 glycerate kinase -
LIO34_RS07305 1455213..1455863 + 651 WP_002935722.1 HAD family hydrolase -
LIO34_RS07310 1455894..1456529 - 636 WP_002935723.1 phosphoserine phosphatase SerB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T220421 WP_009910443.1 NZ_CP085085:c1451308-1451048 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

>T220421 NZ_CP117020:542053-542229 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTCAG
GTTTCACGGGAGGCGCAGTGTCATGCCGCGTCACCCCAGCGAAGAGATTAAAGAACCATTGCGTAAAGCCATTCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT220421 WP_012775256.1 NZ_CP085085:c1451531-1451310 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT220421 NZ_CP117020:542275-542691 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATCAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAAAT
TACTCGCTTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References