Detailed information of TA system TA022042

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2206896..2208455
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: ENT638_RS10520
• Protein ID: WP_012017424.1
• Coordinates: 2206896..2208203 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3S5XQW5
• Locus tag: ENT638_RS10525
• Protein ID: WP_012017425.1
• Coordinates: 2208204..2208455 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS10490	2201955..2202725	+	771	WP_012017419.1	(S)-acetoin forming diacetyl reductase	-
ENT638_RS22275	2203118..2203405	+	288	WP_012017420.1	VF530 family protein	-
ENT638_RS10505	2203412..2204719	+	1308	WP_012017421.1	glycoside hydrolase family 10 protein	-
ENT638_RS10510	2204732..2205493	-	762	WP_012017422.1	thiol:disulfide interchange protein DsbG	-
ENT638_RS10515	2205534..2206754	-	1221	WP_012017423.1	diguanylate phosphodiesterase	-
ENT638_RS10520	2206896..2208203	-	1308	WP_012017424.1	type II toxin-antitoxin system HipA family toxin	Toxin
ENT638_RS10525	2208204..2208455	-	252	WP_012017425.1	helix-turn-helix domain-containing protein	Antitoxin
ENT638_RS10530	2208542..2209006	-	465	WP_012017426.1	helix-turn-helix transcriptional regulator	-
ENT638_RS10535	2209100..2210308	+	1209	WP_012017427.1	MFS transporter	-
ENT638_RS10540	2210241..2211758	-	1518	WP_012017428.1	alpha/beta hydrolase	-
ENT638_RS10545	2211850..2212812	+	963	WP_049759336.1	mannuronate-specific alginate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 48933.99 Da
• Isoelectric Point: 7.7695

>T22042 WP_012017424.1 NC_009436:c2208203-2206896 [Enterobacter sp. 638]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWRYAQTWLDTPGARVISQSLPLTPRRQEGEAVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMHATPLSDNEIAALLEGYRNAPLGMTDDQDFRISIAGAQEKTA
LLWHQDCWQRPTGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFAVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIADIMTLLLGSRRSNQDRETFFRTQIFYWLIGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPIFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSATRAKKMMVEMGGMTNEV
IERVRESLPVDFPTHISEAIFNGMAKQAERLIGSE

Nucleotide

• Length: 1308 bp

>T22042 NC_009436:c2208203-2206896 [Enterobacter sp. 638]
ATGAAAACCAGTAAACTGACCGTTGCGATGAACGGAACCGTTGTCGGCACGCTGTATCGTAACGGCAAAGGGGCGATGTC
CTGGCGCTATGCGCAGACATGGCTCGACACGCCGGGCGCGCGCGTGATTTCGCAGTCGCTACCGTTAACGCCGCGTCGTC
AGGAAGGCGAGGCTGTGTATAACTTCTTTAGCAATCTGCTGCCTGATTCGCAGGCGATTATCTCGCGCATGCAAACGCGC
TTTAAAATCCCTACTGACCATCCTTTTGATTTACTGGCAAGCGTTGGCCGCGACTGTGTAGGCGCAATCCAGCTCTACCC
GGAAAACAGTGAAATACCGCCGGTGACGCACATGCACGCCACGCCGCTTTCGGATAACGAGATTGCGGCCCTGCTGGAAG
GGTATCGTAATGCGCCGTTAGGGATGACCGACGACCAGGACTTCAGGATCTCCATTGCCGGTGCGCAAGAAAAAACGGCG
CTGCTCTGGCATCAGGATTGCTGGCAACGGCCCACCGGCAGCACGCCAACCAGTCATATTTTCAAACTGCCCATCGGCAA
AATTGAACAGAACAATATTGATCTGAGTGAAAGCTGTGAGAATGAGTGGCTGTGTTTACGTCTTGCGCGTGAGTTCGGTT
TTGCGGTAGCGGAGGCCACGTTAGCGACATATGCCGACAAGAAAGTGCTGATTGTCGAGCGTTTTGATCGTAAATGGTCT
CGAGACGGAAAGTGGCTAATGCGCCTCCCGCAAGAAGATATGTGTCAGGCTCTCGGCTATTCACCTGCGCTAAAGTATGA
ATCTCACGGCGGGCCAGGCATCGCCGACATCATGACCTTGCTGCTGGGATCGCGCCGTTCAAACCAGGATCGCGAAACGT
TTTTCCGCACGCAGATATTTTACTGGCTGATAGGCGCGATCGATGGGCATGCAAAAAATTACAGTGTGTTTATCGAACCC
GATTCGGCTTACGTGATGACGCCGCTTTACGATATTTTGTCGGCCTATCCCATCTTCGGGCCAAAGGGTATTTCTGCGCA
AAAAGCGAAAATGGCCATGGCGCTGCAGGGCAAAAACCGGCAATACCACTGGGCTCAAATTCAACCACGTCATTTCCCGG
CCACGGCCGAGCGTGTTGGTTTTTCTGCTACGCGCGCGAAAAAGATGATGGTTGAAATGGGCGGTATGACAAATGAGGTT
ATCGAGCGGGTGCGTGAGTCGTTACCGGTTGATTTCCCGACACATATCAGCGAAGCGATTTTTAACGGTATGGCGAAACA
AGCGGAAAGGCTAATAGGTTCAGAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9323.55 Da
• Isoelectric Point: 5.0790

>AT22042 WP_012017425.1 NC_009436:c2208455-2208204 [Enterobacter sp. 638]
MKITTSTMLANAMRDQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVVPRGQASEKDSGWT
QEW

Nucleotide

• Length: 252 bp

>AT22042 NC_009436:c2208455-2208204 [Enterobacter sp. 638]
ATGAAAATTACCACATCAACCATGCTGGCCAATGCCATGCGAGACCAGCGCAAAGCACTGGAACTGACTCAAGCAGAAGC
CGCCGAGCGCGTGGGGATGAAGCAAACCACAGTATCAGGCTTTGAACAAAACCCGGATACCAGCAAGCTGGAGACGTTGT
TTCGTCTGCTTTCGGCACTGGATTTGGAACTGCACGTCGTGCCCCGGGGCCAGGCGTCAGAAAAGGACAGCGGCTGGACG
CAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3S5XQW5