220418

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 992483..992969 Replicon chromosome
Accession NZ_CP085085
Organism Streptococcus suis strain Ssuis_MA8

Toxin (Protein)


Gene name relE Uniprot ID A0A0K2E5U8
Locus tag LIO34_RS05055 Protein ID WP_002935012.1
Coordinates 992483..992740 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0K2E5B0
Locus tag LIO34_RS05060 Protein ID WP_002935014.1
Coordinates 992730..992969 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO34_RS05035 988117..989187 + 1071 WP_002935006.1 tyrosine recombinase XerS -
LIO34_RS05040 989257..990765 - 1509 WP_013730362.1 phosphoglucomutase -
LIO34_RS05045 990841..991782 - 942 WP_002935009.1 sensor histidine kinase -
LIO34_RS05050 991779..992444 - 666 WP_009909826.1 response regulator transcription factor -
LIO34_RS05055 992483..992740 - 258 WP_002935012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO34_RS05060 992730..992969 - 240 WP_002935014.1 DUF6290 family protein Antitoxin
LIO34_RS05065 993061..995031 - 1971 WP_013730363.1 FtsX-like permease family protein -
LIO34_RS05070 995032..995784 - 753 WP_002935019.1 ABC transporter ATP-binding protein -
LIO34_RS05075 995801..996184 - 384 WP_002935021.1 NisI/SpaI family lantibiotic immunity lipoprotein -
LIO34_RS05080 996197..996337 - 141 WP_002935023.1 hypothetical protein -
LIO34_RS05085 996436..997170 - 735 WP_002935025.1 TraX family protein -
LIO34_RS05090 997183..997320 - 138 WP_002935027.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-75)

Antitoxin

Protein of unknown function DUF6290

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9849.52 Da        Isoelectric Point: 10.7134

>T220418 WP_002935012.1 NZ_CP085085:c992740-992483 [Streptococcus suis]
MSYKVILSAKAQKQIRKMDKTAASLILRYLYKHIDGCDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

>T220418 NZ_CP117020:c210611-210117 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.19 Da        Isoelectric Point: 3.9191

>AT220418 WP_002935014.1 NZ_CP085085:c992969-992730 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADVAWAEYQADLANRIEPMTLEQMAEELGIEL

Download         Length: 240 bp

>AT220418 NZ_CP117020:c210901-210608 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E5U8

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E5B0

References