220417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 499179..499665 Replicon chromosome
Accession NZ_CP085085
Organism Streptococcus suis strain Ssuis_MA8

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag LIO34_RS02660 Protein ID WP_011922754.1
Coordinates 499396..499665 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag LIO34_RS02655 Protein ID WP_002938604.1
Coordinates 499179..499406 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO34_RS02630 494511..495056 - 546 WP_009909618.1 NADPH-dependent FMN reductase -
LIO34_RS02635 495119..495568 - 450 WP_009909619.1 MarR family transcriptional regulator -
LIO34_RS02640 495871..496368 + 498 WP_002938611.1 DUF5590 domain-containing protein -
LIO34_RS02645 496365..497546 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
LIO34_RS02650 497561..498907 + 1347 WP_013730302.1 asparagine--tRNA ligase -
LIO34_RS02655 499179..499406 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
LIO34_RS02660 499396..499665 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIO34_RS02665 500071..501390 + 1320 WP_002937278.1 MATE family efflux transporter -
LIO34_RS02670 501574..501951 + 378 WP_013730303.1 RidA family protein -
LIO34_RS02675 501973..502860 + 888 WP_002937261.1 RNase adapter RapZ -
LIO34_RS02680 502857..503831 + 975 WP_002937257.1 YvcK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T220417 WP_011922754.1 NZ_CP085085:499396-499665 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T220417 NZ_CP117017:26658-26936 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCATCCCCATTTTGTTCTGGTTTATGAAGTCGATAGCCAGTGGGGTAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT220417 WP_002938604.1 NZ_CP085085:499179-499406 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT220417 NZ_CP117017:26389-26658 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGTGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGCGCAGGAAGGTTGCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References