Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 1115917..1117175 | Replicon | chromosome |
| Accession | NZ_CP085082 | ||
| Organism | Pseudomonas aeruginosa strain PAO1-Holloway | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9I4U4 |
| Locus tag | LIO20_RS05335 | Protein ID | WP_003112528.1 |
| Coordinates | 1116420..1117175 (+) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | LIO20_RS05330 | Protein ID | WP_003086329.1 |
| Coordinates | 1115917..1116285 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LIO20_RS05310 (LIO20_05310) | 1112080..1112355 | + | 276 | WP_010793902.1 | zinc ribbon domain-containing protein | - |
| LIO20_RS05315 (LIO20_05315) | 1112358..1112834 | - | 477 | WP_003112531.1 | hypothetical protein | - |
| LIO20_RS05320 (LIO20_05320) | 1112913..1114502 | + | 1590 | WP_010895535.1 | aldehyde dehydrogenase family protein | - |
| LIO20_RS05325 (LIO20_05325) | 1114558..1115844 | + | 1287 | WP_003112529.1 | FAD-binding oxidoreductase | - |
| LIO20_RS05330 (LIO20_05330) | 1115917..1116285 | + | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| LIO20_RS05335 (LIO20_05335) | 1116420..1117175 | + | 756 | WP_003112528.1 | RES family NAD+ phosphorylase | Toxin |
| LIO20_RS05340 (LIO20_05340) | 1117943..1119304 | + | 1362 | WP_010895536.1 | DNA recombination protein RmuC | - |
| LIO20_RS05345 (LIO20_05345) | 1119459..1122002 | - | 2544 | WP_003112526.1 | acyl-homoserine-lactone acylase QuiP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28278.42 Da Isoelectric Point: 7.7294
>T220411 WP_003112528.1 NZ_CP085082:1116420-1117175 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
>T220411 NZ_CP117016:c3798534-3798382 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT220411 WP_003086329.1 NZ_CP085082:1115917-1116285 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
>AT220411 NZ_CP117016:3798583-3798640 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|