Detailed information of TA system TA022041

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1043796..1044416
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A2S5C408
• Locus tag: ENT638_RS04875
• Protein ID: WP_012016344.1
• Coordinates: 1043796..1044014 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: ENT638_RS04880
• Protein ID: WP_012016345.1
• Coordinates: 1044042..1044416 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS04845	1039803..1040063	+	261	WP_012016339.1	type B 50S ribosomal protein L31	-
ENT638_RS04850	1040066..1040206	+	141	WP_003859006.1	type B 50S ribosomal protein L36	-
ENT638_RS04855	1040203..1040913	-	711	WP_012016340.1	GNAT family N-acetyltransferase	-
ENT638_RS04860	1041013..1042473	+	1461	WP_012016341.1	PLP-dependent aminotransferase family protein	-
ENT638_RS04865	1042445..1042912	-	468	WP_012016342.1	membrane protein	-
ENT638_RS04870	1043030..1043581	-	552	WP_012016343.1	maltose O-acetyltransferase	-
ENT638_RS04875	1043796..1044014	-	219	WP_012016344.1	hemolysin expression modulator Hha	Toxin
ENT638_RS04880	1044042..1044416	-	375	WP_012016345.1	Hha toxicity modulator TomB	Antitoxin
ENT638_RS04885	1044925..1048074	-	3150	WP_012016346.1	multidrug efflux RND transporter permease subunit	-
ENT638_RS04890	1048097..1049290	-	1194	WP_012016347.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8631.05 Da
• Isoelectric Point: 8.9039

>T22041 WP_012016344.1 NC_009436:c1044014-1043796 [Enterobacter sp. 638]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Nucleotide

• Length: 219 bp

>T22041 NC_009436:c1044014-1043796 [Enterobacter sp. 638]
ATGTCTGATAAACCATTAACCAAGACAGATTATTTGATGCGTTTGCGTCGCTGTCAGTCACTCGACACCCTTGAACGTGT
TATTGAAAAGAATAAATATGAGCTGCCCGATCATGAACTGGCTGTATTTTATTCAGCCGCCGACCATCGTCTTGCCGAGC
TCACTATGAATAAGCTGTATGACAAAATCCCGGTTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14523.23 Da
• Isoelectric Point: 5.1481

>AT22041 WP_012016345.1 NC_009436:c1044416-1044042 [Enterobacter sp. 638]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFSNVSRANPVSHSC

Nucleotide

• Length: 375 bp

>AT22041 NC_009436:c1044416-1044042 [Enterobacter sp. 638]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTTAATGATCCGACCTCTGCAATCAACTTACAGCTTAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGCATTAACACACAAGACTTGCAAAAATGGCGTAAATCAGGAAATCGGCT
ATTCCGTTGTTTCAGCAACGTCAGCAGAGCTAATCCGGTAAGTCATTCCTGTTAG

Structures

Toxin

• AlphaFold DB: A0A2S5C408