Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1043796..1044416 Replicon chromosome
Accession NC_009436
Organism Enterobacter sp. 638

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5C408
Locus tag ENT638_RS04875 Protein ID WP_012016344.1
Coordinates 1043796..1044014 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag ENT638_RS04880 Protein ID WP_012016345.1
Coordinates 1044042..1044416 (-) Length 125 a.a.

Genomic Context

ENT638_RS04845ENT638_RS04850ENT638_RS04860ENT638_RS04855ENT638_RS04865ENT638_RS04870ENT638_RS04875ENT638_RS04880ENT638_RS04885ENT638_RS04890
Location: 1039803..1040063 (261 bp)
Type: Others
Protein ID: WP_012016339.1
Location: 1040066..1040206 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 1041013..1042473 (1461 bp)
Type: Others
Protein ID: WP_012016341.1
Location: 1040203..1040913 (711 bp)
Type: Others
Protein ID: WP_012016340.1
Location: 1042445..1042912 (468 bp)
Type: Others
Protein ID: WP_012016342.1
Location: 1043030..1043581 (552 bp)
Type: Others
Protein ID: WP_012016343.1
Location: 1043796..1044014 (219 bp)
Type: Toxin
Protein ID: WP_012016344.1
Location: 1044042..1044416 (375 bp)
Type: Antitoxin
Protein ID: WP_012016345.1
Location: 1044925..1048074 (3150 bp)
Type: Others
Protein ID: WP_012016346.1
Location: 1048097..1049290 (1194 bp)
Type: Others
Protein ID: WP_012016347.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ENT638_RS048451039803..1040063+261WP_012016339.1type B 50S ribosomal protein L31-
ENT638_RS048501040066..1040206+141WP_003859006.1type B 50S ribosomal protein L36-
ENT638_RS048551040203..1040913-711WP_012016340.1GNAT family N-acetyltransferase-
ENT638_RS048601041013..1042473+1461WP_012016341.1PLP-dependent aminotransferase family protein-
ENT638_RS048651042445..1042912-468WP_012016342.1membrane protein-
ENT638_RS048701043030..1043581-552WP_012016343.1maltose O-acetyltransferase-
ENT638_RS048751043796..1044014-219WP_012016344.1hemolysin expression modulator HhaToxin
ENT638_RS048801044042..1044416-375WP_012016345.1Hha toxicity modulator TomBAntitoxin
ENT638_RS048851044925..1048074-3150WP_012016346.1multidrug efflux RND transporter permease subunit-
ENT638_RS048901048097..1049290-1194WP_012016347.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.05 Da        Isoelectric Point: 8.9039

>T22041 WP_012016344.1 NC_009436:c1044014-1043796 [Enterobacter sp. 638]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Download         Length: 219 bp

>T22041 NC_009436:c1044014-1043796 [Enterobacter sp. 638]
ATGTCTGATAAACCATTAACCAAGACAGATTATTTGATGCGTTTGCGTCGCTGTCAGTCACTCGACACCCTTGAACGTGT
TATTGAAAAGAATAAATATGAGCTGCCCGATCATGAACTGGCTGTATTTTATTCAGCCGCCGACCATCGTCTTGCCGAGC
TCACTATGAATAAGCTGTATGACAAAATCCCGGTTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14523.23 Da        Isoelectric Point: 5.1481

>AT22041 WP_012016345.1 NC_009436:c1044416-1044042 [Enterobacter sp. 638]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFSNVSRANPVSHSC

Download         Length: 375 bp

>AT22041 NC_009436:c1044416-1044042 [Enterobacter sp. 638]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGCAACCATGGCTGGGTTAATGATCCGACCTCTGCAATCAACTTACAGCTTAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGCATTAACACACAAGACTTGCAAAAATGGCGTAAATCAGGAAATCGGCT
ATTCCGTTGTTTCAGCAACGTCAGCAGAGCTAATCCGGTAAGTCATTCCTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2S5C408

Antitoxin

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Source
ID
Structure
No matching records found

References