Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 143348..143853 | Replicon | chromosome |
Accession | NZ_CP085082 | ||
Organism | Pseudomonas aeruginosa strain PAO1-Holloway |
Toxin (Protein)
Gene name | parE | Uniprot ID | V6A7K8 |
Locus tag | LIO20_RS00660 | Protein ID | WP_003083773.1 |
Coordinates | 143348..143629 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | Q9I707 |
Locus tag | LIO20_RS00665 | Protein ID | WP_003112628.1 |
Coordinates | 143626..143853 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LIO20_RS00635 (LIO20_00635) | 138599..139948 | + | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
LIO20_RS00640 (LIO20_00640) | 139997..140683 | + | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
LIO20_RS00645 (LIO20_00645) | 140784..141518 | + | 735 | WP_003115036.1 | GntR family transcriptional regulator | - |
LIO20_RS00650 (LIO20_00650) | 141698..142108 | + | 411 | WP_003101225.1 | aegerolysin family protein | - |
LIO20_RS00655 (LIO20_00655) | 142140..143048 | - | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
LIO20_RS00660 (LIO20_00660) | 143348..143629 | - | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
LIO20_RS00665 (LIO20_00665) | 143626..143853 | - | 228 | WP_003112628.1 | CopG family ribbon-helix-helix protein | Antitoxin |
LIO20_RS00670 (LIO20_00670) | 144029..144649 | - | 621 | WP_003101226.1 | hypothetical protein | - |
LIO20_RS00675 (LIO20_00675) | 144750..145250 | + | 501 | WP_003112629.1 | LEA type 2 family protein | - |
LIO20_RS00680 (LIO20_00680) | 145323..145664 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
LIO20_RS00685 (LIO20_00685) | 145746..147173 | - | 1428 | WP_003083784.1 | GABA permease | - |
LIO20_RS00690 (LIO20_00690) | 147342..148835 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T220409 WP_003083773.1 NZ_CP085082:c143629-143348 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T220409 NZ_CP117016:3522252-3522542 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT220409 WP_003112628.1 NZ_CP085082:c143853-143626 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
Download Length: 228 bp
>AT220409 NZ_CP117016:3522020-3522262 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGACTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGACTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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