Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143348..143853 Replicon chromosome
Accession NZ_CP085082
Organism Pseudomonas aeruginosa strain PAO1-Holloway

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LIO20_RS00660 Protein ID WP_003083773.1
Coordinates 143348..143629 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag LIO20_RS00665 Protein ID WP_003112628.1
Coordinates 143626..143853 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO20_RS00635 (LIO20_00635) 138599..139948 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
LIO20_RS00640 (LIO20_00640) 139997..140683 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
LIO20_RS00645 (LIO20_00645) 140784..141518 + 735 WP_003115036.1 GntR family transcriptional regulator -
LIO20_RS00650 (LIO20_00650) 141698..142108 + 411 WP_003101225.1 aegerolysin family protein -
LIO20_RS00655 (LIO20_00655) 142140..143048 - 909 WP_003083769.1 LysR family transcriptional regulator -
LIO20_RS00660 (LIO20_00660) 143348..143629 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LIO20_RS00665 (LIO20_00665) 143626..143853 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
LIO20_RS00670 (LIO20_00670) 144029..144649 - 621 WP_003101226.1 hypothetical protein -
LIO20_RS00675 (LIO20_00675) 144750..145250 + 501 WP_003112629.1 LEA type 2 family protein -
LIO20_RS00680 (LIO20_00680) 145323..145664 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
LIO20_RS00685 (LIO20_00685) 145746..147173 - 1428 WP_003083784.1 GABA permease -
LIO20_RS00690 (LIO20_00690) 147342..148835 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T220409 WP_003083773.1 NZ_CP085082:c143629-143348 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T220409 NZ_CP117016:3522252-3522542 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT220409 WP_003112628.1 NZ_CP085082:c143853-143626 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT220409 NZ_CP117016:3522020-3522262 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGACTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References