Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4872863..4873479 Replicon chromosome
Accession NZ_CP085080
Organism Enterobacter cloacae strain ECl_1.VN

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LH408_RS23030 Protein ID WP_080292722.1
Coordinates 4872863..4873234 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LH408_RS23035 Protein ID WP_226835381.1
Coordinates 4873237..4873479 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH408_RS23015 (LH408_23015) 4870363..4871265 + 903 WP_226835379.1 formate dehydrogenase subunit beta -
LH408_RS23020 (LH408_23020) 4871262..4871897 + 636 WP_226835380.1 formate dehydrogenase cytochrome b556 subunit -
LH408_RS23025 (LH408_23025) 4871894..4872823 + 930 WP_029882351.1 formate dehydrogenase accessory protein FdhE -
LH408_RS23030 (LH408_23030) 4872863..4873234 - 372 WP_080292722.1 type II toxin-antitoxin system VapC family toxin Toxin
LH408_RS23035 (LH408_23035) 4873237..4873479 - 243 WP_226835381.1 ribbon-helix-helix domain-containing protein Antitoxin
LH408_RS23040 (LH408_23040) 4873679..4874596 + 918 WP_226835382.1 alpha/beta hydrolase -
LH408_RS23045 (LH408_23045) 4874609..4875550 - 942 WP_013099362.1 fatty acid biosynthesis protein FabY -
LH408_RS23050 (LH408_23050) 4875595..4876032 - 438 WP_226835383.1 D-aminoacyl-tRNA deacylase -
LH408_RS23055 (LH408_23055) 4876029..4876910 - 882 WP_226835384.1 virulence factor BrkB family protein -
LH408_RS23060 (LH408_23060) 4876904..4877503 - 600 WP_013099365.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13625.69 Da        Isoelectric Point: 6.6407

>T220408 WP_080292722.1 NZ_CP085080:c4873234-4872863 [Enterobacter cloacae]
VNNMAVFDTNILIDLFNNRVEAADAIDHAASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFSGIDEVVTPYQL

Download         Length: 372 bp

>T220408 NZ_CP117016:3510651-3511001 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9355.65 Da        Isoelectric Point: 4.4076

>AT220408 WP_226835381.1 NZ_CP085080:c4873479-4873237 [Enterobacter cloacae]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRGALGLWGDKKEDGLEYERKLREEW

Download         Length: 243 bp

>AT220408 NZ_CP117016:3510406-3510657 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References