Detailed information of TA system TA022040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 544357..544884
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ENT638_RS02520
• Protein ID: WP_012015892.1
• Coordinates: 544609..544884 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4HV71
• Locus tag: ENT638_RS02515
• Protein ID: WP_004155191.1
• Coordinates: 544357..544605 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS02480	539380..540465	-	1086	WP_012015885.1	DNA sulfur modification protein DndB	-
ENT638_RS23630	541147..541447	-	301	Protein_485	hypothetical protein	-
ENT638_RS22470	541444..541788	-	345	WP_150099604.1	hypothetical protein	-
ENT638_RS23635	541755..541904	+	150	Protein_487	antirestriction protein	-
ENT638_RS02490	541914..542387	+	474	WP_012015887.1	DNA repair protein RadC	-
ENT638_RS02495	542397..542618	+	222	WP_041689253.1	DUF987 domain-containing protein	-
ENT638_RS02500	542639..542962	+	324	WP_012015889.1	type IV toxin-antitoxin system YeeU family antitoxin	-
ENT638_RS02505	542994..543314	+	321	WP_012015890.1	TA system toxin CbtA family protein	-
ENT638_RS02510	543427..544260	+	834	WP_012015891.1	DUF4942 domain-containing protein	-
ENT638_RS02515	544357..544605	+	249	WP_004155191.1	ribbon-helix-helix domain-containing protein	Antitoxin
ENT638_RS02520	544609..544884	+	276	WP_012015892.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ENT638_RS02525	545015..545908	-	894	WP_012015893.1	HNH endonuclease	-
ENT638_RS02535	546240..547949	-	1710	WP_012015894.1	pectate lyase	-
ENT638_RS02540	548020..548721	-	702	WP_012015895.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11120.50 Da
• Isoelectric Point: 5.5782

>T22040 WP_012015892.1 NC_009436:544609-544884 [Enterobacter sp. 638]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLIIGISGLADHPRIGVSQIRYEPREVRKILFDDYDVHYEIQRDTIY
IVDLWHTREDR

Nucleotide

• Length: 276 bp

>T22040 NC_009436:544609-544884 [Enterobacter sp. 638]
ATGGAAATACAGTGGACCCAAAAGGCCCAGGATGATCTGGAGCGTATTTATAGGTTTGCCTGCCAGTATAGTCGGCAACA
TGCTGACAATGTATTAGAACGTTTGATCATAGGAATCTCAGGGCTCGCCGACCATCCAAGAATCGGTGTATCTCAGATAA
GATATGAACCACGAGAAGTGAGGAAAATTTTGTTTGATGATTATGACGTTCACTATGAAATTCAGCGCGACACTATTTAT
ATTGTTGACCTTTGGCATACCCGAGAGGATCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9121.53 Da
• Isoelectric Point: 8.7560

>AT22040 WP_004155191.1 NC_009436:544357-544605 [Enterobacter sp. 638]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS

Nucleotide

• Length: 249 bp

>AT22040 NC_009436:544357-544605 [Enterobacter sp. 638]
ATGAGACAACTCGCGAAACAGACTATTAGCGCTCAGATCCCTGCAGAGCTTGCAGCTGCGGTTGAAAACCTGGCTATTGA
ACTGGACAGATCCAAAAGCTGGGTGATTAAAGAAGCGCTGACCGCCATGATTGAAGAGAGAGAGCGGCGGCATCAGCAGA
TTTTGAAAGGGCTTGCTGATGTCGATGCGGGAAGGGTGGTTAGCCATGCGGATGTGGTTGACTTCGCTAACAAACTGAAA
AAATCATAA

Structures

Antitoxin

• AlphaFold DB: A0A831A0W7