Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 211549..212153 Replicon chromosome
Accession NZ_CP085080
Organism Enterobacter cloacae strain ECl_1.VN

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag LH408_RS01035 Protein ID WP_071843252.1
Coordinates 211549..211734 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z1F6W0
Locus tag LH408_RS01040 Protein ID WP_013094943.1
Coordinates 211749..212153 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH408_RS01020 (LH408_01020) 207980..209518 + 1539 WP_013094940.1 aldehyde dehydrogenase family protein -
LH408_RS01025 (LH408_01025) 209515..210480 - 966 WP_161657000.1 LysR family transcriptional regulator -
LH408_RS01030 (LH408_01030) 210598..211338 + 741 WP_226835450.1 MipA/OmpV family protein -
LH408_RS01035 (LH408_01035) 211549..211734 + 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
LH408_RS01040 (LH408_01040) 211749..212153 + 405 WP_013094943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LH408_RS01045 (LH408_01045) 212207..214162 - 1956 WP_226835451.1 glycoside hydrolase family 127 protein -
LH408_RS01050 (LH408_01050) 214173..215573 - 1401 WP_226835452.1 MFS transporter -
LH408_RS01055 (LH408_01055) 215798..216616 + 819 WP_020686525.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T220392 WP_071843252.1 NZ_CP085080:211549-211734 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T220392 NZ_CP117013:c4127283-4126885 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTTGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14915.74 Da        Isoelectric Point: 4.3036

>AT220392 WP_013094943.1 NZ_CP085080:211749-212153 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVNEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT220392 NZ_CP117013:c4127579-4127286 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1F6W0

References