Detailed information of TA system TA022039

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 542639..543314
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ENT638_RS02505
• Protein ID: WP_012015890.1
• Coordinates: 542994..543314 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A9J9GE29
• Locus tag: ENT638_RS02500
• Protein ID: WP_012015889.1
• Coordinates: 542639..542962 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS02475	537749..539383	-	1635	WP_012015884.1	DNA phosphorothioation system sulfurtransferase DndC	-
ENT638_RS02480	539380..540465	-	1086	WP_012015885.1	DNA sulfur modification protein DndB	-
ENT638_RS23630	541147..541447	-	301	Protein_485	hypothetical protein	-
ENT638_RS22470	541444..541788	-	345	WP_150099604.1	hypothetical protein	-
ENT638_RS23635	541755..541904	+	150	Protein_487	antirestriction protein	-
ENT638_RS02490	541914..542387	+	474	WP_012015887.1	DNA repair protein RadC	-
ENT638_RS02495	542397..542618	+	222	WP_041689253.1	DUF987 domain-containing protein	-
ENT638_RS02500	542639..542962	+	324	WP_012015889.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ENT638_RS02505	542994..543314	+	321	WP_012015890.1	TA system toxin CbtA family protein	Toxin
ENT638_RS02510	543427..544260	+	834	WP_012015891.1	DUF4942 domain-containing protein	-
ENT638_RS02515	544357..544605	+	249	WP_004155191.1	ribbon-helix-helix domain-containing protein	-
ENT638_RS02520	544609..544884	+	276	WP_012015892.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ENT638_RS02525	545015..545908	-	894	WP_012015893.1	HNH endonuclease	-
ENT638_RS02535	546240..547949	-	1710	WP_012015894.1	pectate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	525229..544605	19376

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-105)

Antitoxin

• Antitoxin CbeA (4-102)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12020.77 Da
• Isoelectric Point: 5.9558

>T22039 WP_012015890.1 NC_009436:542994-543314 [Enterobacter sp. 638]
MHISPVPATVPVLSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIQEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTATDILKAKRATGLINT

Nucleotide

• Length: 321 bp

>T22039 NC_009436:542994-543314 [Enterobacter sp. 638]
ATGCACATTTCTCCTGTACCGGCTACGGTGCCGGTTTTGTCACGCCTGTCGCCCGTACAGGTGTGGCAGCAACTGTTAAC
GTATCTGCTGGAACATCATTACGGCCTAACACTTAACGACACGCCATTCCACGACGACGCGGCCATTCAGGAACATATCG
AGGCGGGAATAACGCTTGCCGATGCGGTGAATTTCTTGGTGGAACGTTATGAACTGGTACGCATCGACCGCAAAGGATTT
ACATGGCAGGAGCAGACACCATTCCTGACCGCGACTGATATTCTCAAAGCCAAGCGAGCTACCGGATTAATAAATACTTG
A

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11931.57 Da
• Isoelectric Point: 6.6244

>AT22039 WP_012015889.1 NC_009436:542639-542962 [Enterobacter sp. 638]
MQNSWGLKRDISPCFSARLVQDGCRLHFLADRAGISGTLNEEDALRLDQAFPLVMKQLELMLTSGELNSRRQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQASATQ

Nucleotide

• Length: 324 bp

>AT22039 NC_009436:542639-542962 [Enterobacter sp. 638]
ATGCAAAATTCATGGGGACTGAAGCGCGACATTTCGCCGTGTTTCAGCGCAAGGTTGGTACAGGATGGTTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGCGGTACGCTTAACGAGGAGGATGCGCTGCGGCTGGATCAGGCGTTTCCGCTAG
TGATGAAGCAGCTTGAATTGATGCTGACATCCGGCGAACTGAATTCGCGCCGTCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAAGCATCTGCAACCCA
GTAA