Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1989..2548 Replicon plasmid unnamed1
Accession NZ_CP085077
Organism Escherichia coli strain P21_SE1_04.20

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag LH372_RS25370 Protein ID WP_000421257.1
Coordinates 2273..2548 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag LH372_RS25365 Protein ID WP_001178089.1
Coordinates 1989..2273 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH372_RS25360 (46) 46..1077 + 1032 WP_023518831.1 plasmid replication initiator RepA -
LH372_RS25365 (1989) 1989..2273 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
LH372_RS25370 (2273) 2273..2548 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH372_RS25375 (2892) 2892..2963 + 72 Protein_3 hypothetical protein -
LH372_RS25380 (3091) 3091..3693 - 603 WP_105457299.1 ProQ/FINO family protein -
LH372_RS25385 (4047) 4047..5393 + 1347 WP_069192007.1 protein YagA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCMY-42 - 1..56811 56811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T220387 WP_000421257.1 NZ_CP085077:2273-2548 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T220387 NZ_CP117013:3021737-3021844 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT220387 WP_001178089.1 NZ_CP085077:1989-2273 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT220387 NZ_CP117013:c3021684-3021623 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References