Detailed information of TA system TA022038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 487436..487952
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ENT638_RS02290
• Protein ID: WP_012015848.1
• Coordinates: 487668..487952 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ENT638_RS02285
• Protein ID: WP_012015847.1
• Coordinates: 487436..487678 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS02270	483382..484122	+	741	WP_012015844.1	KDGP aldolase family protein	-
ENT638_RS02275	484283..485428	+	1146	WP_012015845.1	lactonase family protein	-
ENT638_RS02280	485448..487358	+	1911	WP_012015846.1	BglG family transcription antiterminator	-
ENT638_RS02285	487436..487678	+	243	WP_012015847.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ENT638_RS02290	487668..487952	+	285	WP_012015848.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ENT638_RS02295	487954..488418	-	465	WP_012015849.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ENT638_RS02300	488578..490716	-	2139	WP_012015850.1	anaerobic ribonucleoside-triphosphate reductase	-
ENT638_RS02305	491092..492747	-	1656	WP_012015851.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11018.04 Da
• Isoelectric Point: 10.3778

>T22038 WP_012015848.1 NC_009436:487668-487952 [Enterobacter sp. 638]
MTYELAFDPRALKEWYKLGDTVRAQFKKKLAQVLAEPRIKSARLTDLPDCYKIKLRASGYRLVYQVRDDVVMVFVIAVGK
REKLVVYHDANKRL

Nucleotide

• Length: 285 bp

>T22038 NC_009436:487668-487952 [Enterobacter sp. 638]
ATGACTTATGAACTCGCGTTCGATCCGCGTGCGCTTAAAGAGTGGTACAAGCTGGGCGATACGGTAAGAGCTCAGTTTAA
GAAGAAACTAGCGCAAGTGCTGGCGGAACCCCGGATTAAATCTGCCCGTTTAACGGATTTGCCTGACTGCTACAAAATCA
AGCTAAGAGCATCTGGCTATCGTCTGGTTTACCAGGTGCGTGATGACGTGGTGATGGTCTTCGTCATAGCGGTAGGGAAA
CGCGAGAAATTAGTCGTTTATCATGACGCCAATAAACGACTGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8988.28 Da
• Isoelectric Point: 4.5203

>AT22038 WP_012015847.1 NC_009436:487436-487678 [Enterobacter sp. 638]
MATLNVRLDDKLKNEAYAVLEKLNLTPTEAVRLLFQYVAETGRMPVKTVTISDSEEALIQTVRERLNSPQNGIQVSLDDL

Nucleotide

• Length: 243 bp

>AT22038 NC_009436:487436-487678 [Enterobacter sp. 638]
ATGGCAACGCTGAACGTCCGTCTGGACGATAAACTTAAAAATGAGGCTTACGCGGTGCTGGAAAAACTTAACCTTACCCC
GACAGAAGCGGTGCGCCTGCTATTCCAGTATGTGGCAGAAACCGGACGTATGCCGGTGAAGACGGTCACGATTAGCGATA
GCGAAGAAGCCCTAATCCAAACCGTCCGCGAGCGGCTAAATAGCCCGCAAAATGGTATCCAGGTTAGTTTGGATGACTTA
TGA