Detailed information of TA system TA022036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 268730..269327
• Replicon: chromosome
• Accession: NC_009436
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: ENT638_RS01225
• Protein ID: WP_011915488.1
• Coordinates: 269010..269327 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: ENT638_RS01220
• Protein ID: WP_011915487.1
• Coordinates: 268730..269017 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS01215	267102..268733	+	1632	WP_011915486.1	Na/Pi cotransporter family protein	-
ENT638_RS01220	268730..269017	-	288	WP_011915487.1	putative addiction module antidote protein	Antitoxin
ENT638_RS01225	269010..269327	-	318	WP_011915488.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ENT638_RS01230	269517..270386	+	870	WP_011915489.1	23S rRNA pseudouridine(2604) synthase RluF	-
ENT638_RS01235	270387..270659	-	273	WP_011915490.1	DUF3811 domain-containing protein	-
ENT638_RS01240	270722..271666	-	945	WP_011915491.1	ketopantoate/pantoate/pantothenate transporter PanS	-
ENT638_RS01245	271760..273109	-	1350	WP_011915492.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (2-89)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11993.73 Da
• Isoelectric Point: 10.5793

>T22036 WP_011915488.1 NC_009436:c269327-269010 [Enterobacter sp. 638]
MKEIVQTESFRRWEQNVNDPRAKTLIAARLFRLANGLPGDVRPVGEGISELRIHYGPGYRIYFKSHGNTLIILLSGGNKN
SQDKDIILAKTLARSLKHREFTHHD

Nucleotide

• Length: 318 bp

>T22036 NC_009436:c269327-269010 [Enterobacter sp. 638]
ATGAAGGAGATTGTTCAAACAGAATCCTTTCGTCGCTGGGAGCAAAACGTAAACGATCCGCGTGCCAAGACACTCATTGC
AGCACGTTTGTTCCGCCTGGCGAATGGGCTGCCTGGTGATGTAAGACCTGTCGGAGAAGGTATCAGCGAGCTACGAATTC
ATTACGGCCCGGGTTACCGGATCTATTTTAAATCGCACGGAAACACACTGATCATTTTGCTCAGTGGCGGCAATAAAAAC
AGTCAGGATAAAGACATCATTCTGGCAAAGACACTCGCAAGGTCACTCAAACACCGGGAGTTTACACACCATGACTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10137.58 Da
• Isoelectric Point: 5.7903

>AT22036 WP_011915487.1 NC_009436:c269017-268730 [Enterobacter sp. 638]
MTELTHYDPARALINDDEISVFMADALETGDSAYIAQALGVVARAKGMSTIASQTGLSREQLYRSFSKKGNPTLKTTLAV
MKALGLGLTIKSAED

Nucleotide

• Length: 288 bp

>AT22036 NC_009436:c269017-268730 [Enterobacter sp. 638]
ATGACTGAACTCACTCATTACGATCCTGCCAGGGCGCTTATCAATGATGATGAAATTAGCGTATTCATGGCTGATGCGCT
AGAAACTGGCGATTCTGCCTACATTGCTCAAGCATTAGGGGTCGTTGCCCGCGCAAAAGGAATGTCTACGATTGCGTCAC
AAACGGGTTTGTCTCGCGAACAGCTGTACCGCTCTTTTAGTAAAAAGGGTAACCCAACGCTTAAAACCACACTTGCCGTT
ATGAAAGCGCTGGGTCTTGGATTGACGATCAAAAGTGCCGAAGATTAA