Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 836548..837380 Replicon chromosome
Accession NZ_CP085074
Organism Escherichia coli strain P21_SE1_04.20

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag LH372_RS04030 Protein ID WP_000854765.1
Coordinates 836548..836922 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag LH372_RS04035 Protein ID WP_001295723.1
Coordinates 837012..837380 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH372_RS03995 (831626) 831626..832225 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
LH372_RS04000 (832228) 832228..833205 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
LH372_RS04005 (833202) 833202..834380 + 1179 WP_000094991.1 type II secretion system protein GspL -
LH372_RS04010 (834382) 834382..834918 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
LH372_RS04015 (835199) 835199..836041 - 843 WP_022645115.1 DUF4942 domain-containing protein -
LH372_RS04020 (836126) 836126..836320 - 195 WP_024181941.1 DUF957 domain-containing protein -
LH372_RS04025 (836345) 836345..836548 - 204 WP_001398797.1 DUF5983 family protein -
LH372_RS04030 (836548) 836548..836922 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
LH372_RS04035 (837012) 837012..837380 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LH372_RS04040 (837543) 837543..837764 - 222 WP_000692341.1 DUF987 domain-containing protein -
LH372_RS04045 (837827) 837827..838303 - 477 WP_001186774.1 RadC family protein -
LH372_RS04050 (838319) 838319..838798 - 480 WP_057109541.1 antirestriction protein -
LH372_RS04055 (839064) 839064..839882 - 819 WP_001175165.1 DUF932 domain-containing protein -
LH372_RS04060 (839972) 839972..840205 - 234 WP_001278293.1 DUF905 family protein -
LH372_RS04065 (840211) 840211..840888 - 678 WP_001097302.1 hypothetical protein -
LH372_RS04070 (841036) 841036..841716 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T220359 WP_000854765.1 NZ_CP085074:c836922-836548 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T220359 NZ_CP117009:50139-50519 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT220359 WP_001295723.1 NZ_CP085074:c837380-837012 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT220359 NZ_CP117009:49918-50139 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7ZVJ9


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References