Detailed information of TA system TA022034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 146578..147113
• Replicon: plasmid pENTE01
• Accession: NC_009425
• Organism: Enterobacter sp. 638

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ENT638_RS22110
• Protein ID: WP_011906587.1
• Coordinates: 146578..146865 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2W0FTV2
• Locus tag: ENT638_RS22115
• Protein ID: WP_011906588.1
• Coordinates: 146862..147113 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ENT638_RS22090	142052..143071	+	1020	WP_011906584.1	replication initiation protein	-
ENT638_RS22095	144003..144770	-	768	WP_011906585.1	conjugal transfer protein TraX	-
ENT638_RS24115	144762..145133	+	372	WP_190275397.1	hypothetical protein	-
ENT638_RS22100	145370..145693	-	324	WP_150099639.1	hypothetical protein	-
ENT638_RS22105	145794..146072	-	279	WP_041689769.1	hypothetical protein	-
ENT638_RS22110	146578..146865	-	288	WP_011906587.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ENT638_RS22115	146862..147113	-	252	WP_011906588.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ENT638_RS22120	147305..148102	+	798	WP_041689788.1	hypothetical protein	-
ENT638_RS22350	149107..150390	+	1284	WP_011906590.1	YadA-like family protein	-
ENT638_RS22130	150732..151190	+	459	WP_011906591.1	hypothetical protein	-
ENT638_RS23950	151288..151455	+	168	WP_011906592.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..157749	157749

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11107.03 Da
• Isoelectric Point: 10.3849

>T22034 WP_011906587.1 NC_009425:c146865-146578 [Enterobacter sp. 638]
MTYTVKFRDDALKEWMKLDKSIQQQFAKKLKNCSENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Nucleotide

• Length: 288 bp

>T22034 NC_009425:c146865-146578 [Enterobacter sp. 638]
ATGACTTACACAGTCAAATTCAGGGATGATGCGCTGAAAGAGTGGATGAAGCTGGATAAGTCCATTCAGCAGCAATTTGC
TAAAAAGCTGAAGAACTGCAGTGAAAATCCTCATATTCCCTCTGCAAAGCTGCGTGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCTGGTTTTCGCCTGGTCTATCAGGTGATTGACGATCAATTGATTATCGCTGTTGTAGCCGTAGGTAAA
CGCGAAAGAAGTGATGTTTATAATCTGGCAAGCGAACGAATGAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9198.42 Da
• Isoelectric Point: 4.0780

>AT22034 WP_011906588.1 NC_009425:c147113-146862 [Enterobacter sp. 638]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQQLHDVDLD
SYL

Nucleotide

• Length: 252 bp

>AT22034 NC_009425:c147113-146862 [Enterobacter sp. 638]
ATGCCTAATATCATTCTTACCGACACAAGCGCCAGTGTAAGCGAGCTTAAGAAAAATCCGATGGCTACAGTCAGCGCCGG
TGATGGCTACCCGGTTGCTATTCTGAACCGTAACCAGCCAGCCTTTTATTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGATGATCAGGAACTGGTTAAGCTGGTCGCCGAGCGCAGCAACCAGCAACTGCACGACGTGGATCTGGAT
AGCTACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2W0FTV2