Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1866215..1867047 Replicon chromosome
Accession NZ_CP085069
Organism Escherichia coli strain P27_L1_05.20

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag LH371_RS08895 Protein ID WP_000854765.1
Coordinates 1866215..1866589 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LH371_RS08900 Protein ID WP_021548605.1
Coordinates 1866679..1867047 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH371_RS08860 (1861477) 1861477..1861842 - 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
LH371_RS08865 (1862113) 1862113..1862502 - 390 WP_001445118.1 IS110 family transposase -
LH371_RS08870 (1862628) 1862628..1863126 - 499 Protein_1731 transposase -
LH371_RS08875 (1863320) 1863320..1864861 + 1542 WP_001518966.1 IS21-like element ISEc12 family transposase -
LH371_RS08880 (1864876) 1864876..1865628 + 753 Protein_1733 IS21-like element ISEc12 family helper ATPase IstB -
LH371_RS08885 (1865886) 1865886..1865966 - 81 Protein_1734 hypothetical protein -
LH371_RS08890 (1866066) 1866066..1866218 - 153 Protein_1735 DUF5983 family protein -
LH371_RS08895 (1866215) 1866215..1866589 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
LH371_RS08900 (1866679) 1866679..1867047 - 369 WP_021548605.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LH371_RS08905 (1867210) 1867210..1867431 - 222 WP_000692345.1 DUF987 domain-containing protein -
LH371_RS08910 (1867494) 1867494..1867970 - 477 WP_001186775.1 RadC family protein -
LH371_RS08915 (1867986) 1867986..1868459 - 474 WP_001350782.1 antirestriction protein -
LH371_RS08920 (1868801) 1868801..1869619 - 819 WP_001234656.1 DUF932 domain-containing protein -
LH371_RS08925 (1869737) 1869737..1869932 - 196 Protein_1742 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1863320..1966048 102728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T220332 WP_000854765.1 NZ_CP085069:c1866589-1866215 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T220332 NZ_CP117007:139289-139423 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13601.41 Da        Isoelectric Point: 6.7390

>AT220332 WP_021548605.1 NZ_CP085069:c1867047-1866679 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHHHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT220332 NZ_CP117007:c139243-139192 [Escherichia coli]
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7ZVJ9

Antitoxin

Source ID Structure

References