Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1304939..1305564 Replicon chromosome
Accession NZ_CP085069
Organism Escherichia coli strain P27_L1_05.20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LH371_RS06310 Protein ID WP_000911330.1
Coordinates 1305166..1305564 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LH371_RS06305 Protein ID WP_000450524.1
Coordinates 1304939..1305166 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH371_RS06280 (1300742) 1300742..1301212 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LH371_RS06285 (1301212) 1301212..1301784 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LH371_RS06290 (1301930) 1301930..1302808 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LH371_RS06295 (1302825) 1302825..1303859 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LH371_RS06300 (1304072) 1304072..1304785 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LH371_RS06305 (1304939) 1304939..1305166 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LH371_RS06310 (1305166) 1305166..1305564 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LH371_RS06315 (1305711) 1305711..1306574 + 864 WP_001267508.1 neutral zinc metallopeptidase -
LH371_RS06320 (1306589) 1306589..1308604 + 2016 WP_000829354.1 tRNA cytosine(34) acetyltransferase TmcA -
LH371_RS06325 (1308678) 1308678..1309376 + 699 WP_000679812.1 esterase -
LH371_RS06330 (1309457) 1309457..1309657 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T220330 WP_000911330.1 NZ_CP085069:1305166-1305564 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T220330 NZ_CP117007:c63037-62636 [Escherichia coli]
ATGCTCGACACGAATATCTGCTCTTTCATTATGCGTGAACAGCCCGCCGCAGTGATCAAACGTCTGGAGCAGGCGGTGCT
GCGTAACCACCGCATTGTCGTGTCGGCCATCACCTATGCGGAGATGCGTTTCGGCGCCACCGGCCCGAAAGCCTCACCGC
GTCATATTGCGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATTCTGCCCTGGGACCGCGCTGCCGTGGACGCCACC
ACGGAGATTAAAATGGCACTGCGGCTGGCCGGGACGCCAATCGGCCCGAACGACACGGCGATTGCCGGGCACGCCATCGC
TGCCGGGGCGATACTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCTGACCTGGTGCTGGAAGACTGGGTGAAGT
AA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT220330 WP_000450524.1 NZ_CP085069:1304939-1305166 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT220330 NZ_CP117007:c63291-63061 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCCCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTTGAGATCGTCCGCGAAGGAGACAGCATTATATTGCGCCCGGTCCGGCCGACCTGGAGCTCGTTTGCGGCACTCG
AAAAGGCCGACGCAGACTTTATGGCGGAGCGTGAGGACATTGTCAGCGACGAAGGAAGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References