Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 60386..61122 Replicon plasmid pENTE01
Accession NC_009425
Organism Enterobacter sp. 638

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag ENT638_RS21710 Protein ID WP_011906517.1
Coordinates 60386..60868 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag ENT638_RS21715 Protein ID WP_011906518.1
Coordinates 60856..61122 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENT638_RS21695 56798..58195 - 1398 WP_011906515.1 hypothetical protein -
ENT638_RS21700 58466..59671 - 1206 WP_011906516.1 VWA domain-containing protein -
ENT638_RS21710 60386..60868 - 483 WP_011906517.1 GNAT family N-acetyltransferase Toxin
ENT638_RS21715 60856..61122 - 267 WP_011906518.1 DUF1778 domain-containing protein Antitoxin
ENT638_RS21720 61244..61744 - 501 WP_049759462.1 hypothetical protein -
ENT638_RS23260 61829..62008 + 180 WP_063925957.1 thioredoxin family protein -
ENT638_RS21730 62692..63126 + 435 WP_011906519.1 universal stress protein UspF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157749 157749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17670.32 Da        Isoelectric Point: 9.1157

>T22033 WP_011906517.1 NC_009425:c60868-60386 [Enterobacter sp. 638]
VGRVTAPEPLSSTHQLAEFVSGETVLDDWLKQRGLKNQAFRTTRTFVVCKTDMKQVAGFYSLATGSVNHVDSTGSLRHNM
PDPIPVIILARLAVDVSFRGKGIGADLLQDAVLRCYRVAENIGVRAIMVHAMTEEAKSFYVHHGFTASQTQERTLFLKLP

Download         Length: 483 bp

>T22033 NC_009425:c60868-60386 [Enterobacter sp. 638]
GTGGGACGTGTAACAGCACCAGAACCGTTATCCAGTACCCATCAACTGGCTGAGTTCGTCAGCGGGGAGACTGTGCTCGA
TGACTGGCTTAAACAGAGAGGGTTAAAAAATCAGGCATTCAGAACCACCCGTACGTTTGTGGTTTGTAAAACAGACATGA
AACAGGTTGCCGGTTTTTATTCTCTGGCCACCGGCAGTGTTAACCATGTGGATTCTACGGGAAGCCTCAGGCACAATATG
CCCGATCCAATTCCCGTAATTATACTTGCTCGCCTGGCGGTCGATGTTTCATTCCGTGGAAAAGGGATCGGGGCTGATTT
ACTGCAAGATGCAGTTTTACGCTGTTACCGTGTAGCTGAGAACATTGGTGTCCGTGCGATTATGGTTCATGCAATGACTG
AAGAAGCCAAAAGCTTTTATGTCCACCACGGTTTTACTGCATCGCAAACGCAGGAGCGGACGCTGTTTCTTAAGCTTCCA
TAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10099.51 Da        Isoelectric Point: 4.5010

>AT22033 WP_011906518.1 NC_009425:c61122-60856 [Enterobacter sp. 638]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAEHVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT22033 NC_009425:c61122-60856 [Enterobacter sp. 638]
ATGAAATCCGATGTTCAACTCAATCTTAGAGCCAAGGAATCTCAACGAGCACTCATTGATGCTGCAGCAGAGATTCTTCA
TAAATCACGCACAGACTTCATCCTGGAAATGGCATGCCAGGCTGCGGAGCATGTGATCCTCGATCGTCGCGTATTCAATT
TTAACGATGAGCAGTATGCAGAGTTCATCGATATGCTCGATGCACCCGTTGCAGATGACCCTGCCATTGATAAACTTCTG
GCCAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References