Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3143517..3144137 Replicon chromosome
Accession NC_009381
Organism Yersinia pestis Pestoides F

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPDSF_RS14615 Protein ID WP_002208622.1
Coordinates 3143934..3144137 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPDSF_RS14610 Protein ID WP_002218472.1
Coordinates 3143517..3143885 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPDSF_RS14595 3141712..3141972 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
YPDSF_RS14600 3141988..3142131 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPDSF_RS14605 3143005..3143358 + 354 WP_002208619.1 hypothetical protein -
YPDSF_RS14610 3143517..3143885 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPDSF_RS14615 3143934..3144137 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPDSF_RS14620 3145025..3145414 + 390 WP_002208623.1 MGMT family protein -
YPDSF_RS14625 3145550..3146071 - 522 WP_011906379.1 YbaY family lipoprotein -
YPDSF_RS14630 3146328..3147188 + 861 WP_002208625.1 acyl-CoA thioesterase II -
YPDSF_RS14635 3147448..3148737 - 1290 WP_002228344.1 ammonium transporter AmtB -
YPDSF_RS14640 3148777..3149115 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T22032 WP_002208622.1 NC_009381:3143934-3144137 [Yersinia pestis Pestoides F]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T22032 NC_009381:3143934-3144137 [Yersinia pestis Pestoides F]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT22032 WP_002218472.1 NC_009381:3143517-3143885 [Yersinia pestis Pestoides F]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT22032 NC_009381:3143517-3143885 [Yersinia pestis Pestoides F]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCAGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References