Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2618448..2618970 Replicon chromosome
Accession NZ_CP085063
Organism Escherichia coli strain P31_YH1_02.21

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag LH370_RS12750 Protein ID WP_001105433.1
Coordinates 2618448..2618738 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag LH370_RS12755 Protein ID WP_000212715.1
Coordinates 2618728..2618970 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH370_RS12735 (2613611) 2613611..2615266 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
LH370_RS12740 (2615660) 2615660..2617798 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
LH370_RS12745 (2617983) 2617983..2618447 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LH370_RS12750 (2618448) 2618448..2618738 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH370_RS12755 (2618728) 2618728..2618970 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LH370_RS12760 (2619162) 2619162..2619548 - 387 WP_001232246.1 cytochrome b562 -
LH370_RS12765 (2619732) 2619732..2621084 - 1353 WP_001162173.1 metalloprotease PmbA -
LH370_RS12770 (2621178) 2621178..2621729 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
LH370_RS12775 (2621881) 2621881..2623254 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T220307 WP_001105433.1 NZ_CP085063:c2618738-2618448 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T220307 NZ_CP117006:220155-220262 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT220307 WP_000212715.1 NZ_CP085063:c2618970-2618728 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT220307 NZ_CP117006:c220106-220043 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References