Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1897417..1898035 | Replicon | chromosome |
Accession | NZ_CP085063 | ||
Organism | Escherichia coli strain P31_YH1_02.21 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | LH370_RS09325 | Protein ID | WP_001291435.1 |
Coordinates | 1897817..1898035 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | LH370_RS09320 | Protein ID | WP_000344800.1 |
Coordinates | 1897417..1897791 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LH370_RS09310 (1892506) | 1892506..1893699 | + | 1194 | WP_001295833.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
LH370_RS09315 (1893722) | 1893722..1896871 | + | 3150 | WP_001132480.1 | efflux RND transporter permease AcrB | - |
LH370_RS09320 (1897417) | 1897417..1897791 | + | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
LH370_RS09325 (1897817) | 1897817..1898035 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
LH370_RS09330 (1898207) | 1898207..1898758 | + | 552 | WP_001522034.1 | maltose O-acetyltransferase | - |
LH370_RS09335 (1898874) | 1898874..1899344 | + | 471 | WP_001490888.1 | YlaC family protein | - |
LH370_RS09340 (1899508) | 1899508..1901058 | + | 1551 | WP_001577872.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
LH370_RS09345 (1901100) | 1901100..1901453 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
LH370_RS09355 (1901832) | 1901832..1902143 | + | 312 | WP_000409911.1 | MGMT family protein | - |
LH370_RS09360 (1902174) | 1902174..1902746 | - | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T220303 WP_001291435.1 NZ_CP085063:1897817-1898035 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T220303 NZ_CP117004:c42842-42693 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT220303 WP_000344800.1 NZ_CP085063:1897417-1897791 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT220303 NZ_CP117004:42886-42947 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |