Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 597167..597693 | Replicon | chromosome |
| Accession | NZ_CP085063 | ||
| Organism | Escherichia coli strain P31_YH1_02.21 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | LH370_RS03025 | Protein ID | WP_000323025.1 |
| Coordinates | 597406..597693 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | LH370_RS03020 | Protein ID | WP_000534858.1 |
| Coordinates | 597167..597406 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LH370_RS02990 (592429) | 592429..593043 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| LH370_RS02995 (593046) | 593046..594068 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| LH370_RS03000 (594573) | 594573..595595 | + | 1023 | Protein_587 | ISNCY family transposase | - |
| LH370_RS03005 (595716) | 595716..595865 | + | 150 | WP_011443592.1 | protein YdfW | - |
| LH370_RS03010 (596302) | 596302..596634 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| LH370_RS03015 (596837) | 596837..597142 | - | 306 | WP_001326990.1 | protein YdfV | - |
| LH370_RS03020 (597167) | 597167..597406 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| LH370_RS03025 (597406) | 597406..597693 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| LH370_RS03030 (597765) | 597765..597920 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| LH370_RS03035 (598137) | 598137..598388 | + | 252 | WP_000980994.1 | protein Rem | - |
| LH370_RS03040 (598455) | 598455..598733 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| LH370_RS03045 (598735) | 598735..599784 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| LH370_RS03050 (599798) | 599798..600550 | + | 753 | WP_001047135.1 | antitermination protein | - |
| LH370_RS03055 (600828) | 600828..600917 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| LH370_RS03060 (600972) | 600972..601184 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| LH370_RS03065 (601485) | 601485..601700 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| LH370_RS03070 (602064) | 602064..602234 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| LH370_RS03075 (602454) | 602454..602669 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 571024..639727 | 68703 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T220298 WP_000323025.1 NZ_CP085063:597406-597693 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T220298 NZ_CP117001:4097993-4098391 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT220298 WP_000534858.1 NZ_CP085063:597167-597406 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT220298 NZ_CP117001:4097697-4097990 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|