Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3841499..3842331 | Replicon | chromosome |
| Accession | NZ_CP085060 | ||
| Organism | Escherichia coli strain P30_L1_05.20 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | LH369_RS18460 | Protein ID | WP_000854765.1 |
| Coordinates | 3841957..3842331 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | LH369_RS18455 | Protein ID | WP_001295723.1 |
| Coordinates | 3841499..3841867 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LH369_RS18415 (3837163) | 3837163..3837843 | + | 681 | WP_001282921.1 | WYL domain-containing protein | - |
| LH369_RS18420 (3837991) | 3837991..3838668 | + | 678 | WP_001097302.1 | hypothetical protein | - |
| LH369_RS18425 (3838674) | 3838674..3838907 | + | 234 | WP_001278293.1 | DUF905 family protein | - |
| LH369_RS18430 (3838997) | 3838997..3839815 | + | 819 | WP_001175165.1 | DUF932 domain-containing protein | - |
| LH369_RS18435 (3839841) | 3839841..3839981 | - | 141 | WP_000997937.1 | hypothetical protein | - |
| LH369_RS18440 (3840081) | 3840081..3840560 | + | 480 | WP_057109541.1 | antirestriction protein | - |
| LH369_RS18445 (3840576) | 3840576..3841052 | + | 477 | WP_001186774.1 | RadC family protein | - |
| LH369_RS18450 (3841115) | 3841115..3841336 | + | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| LH369_RS18455 (3841499) | 3841499..3841867 | + | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LH369_RS18460 (3841957) | 3841957..3842331 | + | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| LH369_RS18465 (3842331) | 3842331..3842534 | + | 204 | WP_001398797.1 | DUF5983 family protein | - |
| LH369_RS18470 (3842559) | 3842559..3842753 | + | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| LH369_RS18475 (3842838) | 3842838..3843680 | + | 843 | WP_022645115.1 | DUF4942 domain-containing protein | - |
| LH369_RS18480 (3843961) | 3843961..3844497 | - | 537 | WP_000942785.1 | GspM family type II secretion system protein YghD | - |
| LH369_RS18485 (3844499) | 3844499..3845677 | - | 1179 | WP_000094991.1 | type II secretion system protein GspL | - |
| LH369_RS18490 (3845674) | 3845674..3846651 | - | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| LH369_RS18495 (3846654) | 3846654..3847253 | - | 600 | WP_001255034.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T220276 WP_000854765.1 NZ_CP085060:3841957-3842331 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T220276 NZ_CP116996:6520-6822 [Escherichia coli]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTCTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTCTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT220276 WP_001295723.1 NZ_CP085060:3841499-3841867 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT220276 NZ_CP116996:6894-7232 [Escherichia coli]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACAT
GAATAAAAAAGCAGCCTGA
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACAT
GAATAAAAAAGCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|