Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3665065..3665866 | Replicon | chromosome |
| Accession | NZ_CP085056 | ||
| Organism | Escherichia coli strain P24_WM1_05.20 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | LHK10_RS17835 | Protein ID | WP_061091468.1 |
| Coordinates | 3665065..3665442 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | LHK10_RS17840 | Protein ID | WP_032215284.1 |
| Coordinates | 3665489..3665866 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHK10_RS17800 (3661001) | 3661001..3661288 | - | 288 | Protein_3479 | DUF4942 domain-containing protein | - |
| LHK10_RS17805 (3661570) | 3661570..3662574 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| LHK10_RS17810 (3662646) | 3662646..3663206 | - | 561 | Protein_3481 | DUF4942 domain-containing protein | - |
| LHK10_RS17815 (3663303) | 3663303..3663500 | - | 198 | WP_061091469.1 | DUF957 domain-containing protein | - |
| LHK10_RS17820 (3663520) | 3663520..3663669 | - | 150 | Protein_3483 | DUF5983 family protein | - |
| LHK10_RS17825 (3663749) | 3663749..3664666 | + | 918 | WP_000520337.1 | IS5-like element ISEc35 family transposase | - |
| LHK10_RS17830 (3664640) | 3664640..3665068 | - | 429 | Protein_3485 | DUF5983 family protein | - |
| LHK10_RS17835 (3665065) | 3665065..3665442 | - | 378 | WP_061091468.1 | TA system toxin CbtA family protein | Toxin |
| LHK10_RS17840 (3665489) | 3665489..3665866 | - | 378 | WP_032215284.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LHK10_RS17845 (3666029) | 3666029..3666250 | - | 222 | WP_000692307.1 | DUF987 domain-containing protein | - |
| LHK10_RS17850 (3666319) | 3666319..3666795 | - | 477 | WP_001186774.1 | RadC family protein | - |
| LHK10_RS17855 (3666811) | 3666811..3667284 | - | 474 | WP_000855069.1 | antirestriction protein | - |
| LHK10_RS17860 (3667378) | 3667378..3667623 | - | 246 | WP_000680586.1 | hypothetical protein | - |
| LHK10_RS17865 (3667623) | 3667623..3668444 | - | 822 | WP_061091467.1 | DUF932 domain-containing protein | - |
| LHK10_RS17870 (3668812) | 3668812..3669294 | - | 483 | WP_077777324.1 | hypothetical protein | - |
| LHK10_RS17875 (3669655) | 3669655..3670197 | - | 543 | WP_033811096.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE | 3634163..3706671 | 72508 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14223.17 Da Isoelectric Point: 6.7029
>T220245 WP_061091468.1 NZ_CP085056:c3665442-3665065 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTLFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTLFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T220245 NZ_CP116987:c4588938-4588627 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13806.71 Da Isoelectric Point: 6.7387
>AT220245 WP_032215284.1 NZ_CP085056:c3665866-3665489 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT220245 NZ_CP116987:c4588626-4588336 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|