220224

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 376279..376693 Replicon chromosome
Accession NZ_CP085039
Organism Streptomyces sp. WA1-19

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag LH646_RS01765 Protein ID WP_052230981.1
Coordinates 376279..376470 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag LH646_RS01770 Protein ID WP_226964185.1
Coordinates 376472..376693 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH646_RS01740 (LH646_01740) 371279..371812 + 534 WP_030698297.1 YbjN domain-containing protein -
LH646_RS01745 (LH646_01745) 371891..372145 - 255 WP_030698296.1 hypothetical protein -
LH646_RS01750 (LH646_01750) 372462..373673 + 1212 WP_226964184.1 beta-propeller fold lactonase family protein -
LH646_RS01755 (LH646_01755) 373729..375078 - 1350 WP_078858032.1 MFS transporter -
LH646_RS01760 (LH646_01760) 375212..375973 + 762 WP_030698293.1 phosphoglyceromutase -
LH646_RS01765 (LH646_01765) 376279..376470 - 192 WP_052230981.1 hypothetical protein Toxin
LH646_RS01770 (LH646_01770) 376472..376693 - 222 WP_226964185.1 excisionase family DNA-binding protein Antitoxin
LH646_RS01775 (LH646_01775) 376874..377398 + 525 WP_047465879.1 DUF4232 domain-containing protein -
LH646_RS01780 (LH646_01780) 377441..378127 + 687 WP_047465876.1 MOSC domain-containing protein -
LH646_RS01785 (LH646_01785) 378120..378299 + 180 WP_030698289.1 hypothetical protein -
LH646_RS01790 (LH646_01790) 378353..378916 - 564 WP_030698288.1 TetR family transcriptional regulator -
LH646_RS01795 (LH646_01795) 378906..379229 - 324 WP_030698287.1 SMR family transporter -
LH646_RS01800 (LH646_01800) 379351..379518 - 168 WP_165438940.1 hypothetical protein -
LH646_RS01805 (LH646_01805) 379855..380535 - 681 WP_030698286.1 phosphate signaling complex protein PhoU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Helix-turn-helix domain, group 17

(5-52)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7132.27 Da        Isoelectric Point: 5.7414

>T220224 WP_052230981.1 NZ_CP085039:c376470-376279 [Streptomyces sp. WA1-19]
MTFVVLYDACVLYPDTLRDLLVRVARTGLVRARWTEAILDEVDRGIARNHQIPPEKLAPAEPS

Download         Length: 192 bp

>T220224 NZ_CP116987:207782-207889 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8277.43 Da        Isoelectric Point: 5.6558

>AT220224 WP_226964185.1 NZ_CP085039:c376693-376472 [Streptomyces sp. WA1-19]
VGTHSVQQAADMLNVSRPYLIGLLESGEIPFRLVGRHRRIRFADLRQYIREDDAARKGAADDLMELDQELGLL

Download         Length: 222 bp

>AT220224 NZ_CP116987:c207724-207670 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References