Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3661501..3662200 Replicon chromosome
Accession NZ_CP085032
Organism Proteus terrae subsp. cibarius strain ZJ19PC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LHA39_RS16790 Protein ID WP_075671320.1
Coordinates 3661501..3661887 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LHA39_RS16795 Protein ID WP_075671318.1
Coordinates 3661880..3662200 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHA39_RS16775 (LHA39_16775) 3657539..3658123 - 585 WP_159242124.1 DNA-3-methyladenine glycosylase I -
LHA39_RS16780 (LHA39_16780) 3658362..3659267 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
LHA39_RS16785 (LHA39_16785) 3659277..3661349 + 2073 WP_075671322.1 glycine--tRNA ligase subunit beta -
LHA39_RS16790 (LHA39_16790) 3661501..3661887 + 387 WP_075671320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LHA39_RS16795 (LHA39_16795) 3661880..3662200 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
LHA39_RS16800 (LHA39_16800) 3662268..3662588 - 321 WP_075671316.1 hypothetical protein -
LHA39_RS16805 (LHA39_16805) 3662682..3663968 - 1287 WP_159242125.1 DUF3748 domain-containing protein -
LHA39_RS16810 (LHA39_16810) 3664105..3664722 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
LHA39_RS16815 (LHA39_16815) 3665028..3665651 + 624 WP_006534608.1 guanylate kinase -
LHA39_RS16820 (LHA39_16820) 3665706..3665981 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14358.75 Da        Isoelectric Point: 10.0463

>T220221 WP_075671320.1 NZ_CP085032:3661501-3661887 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T220221 NZ_CP116982:155202-155351 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT220221 WP_075671318.1 NZ_CP085032:3661880-3662200 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT220221 NZ_CP116982:c155158-155097 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References