Detailed information of TA system TA022022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 900890..901856
• Replicon: chromosome
• Accession: NC_009381
• Organism: Yersinia pestis Pestoides F

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: YPDSF_RS04205
• Protein ID: WP_002210981.1
• Coordinates: 900890..901348 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: YPDSF_RS04210
• Protein ID: WP_002210982.1
• Coordinates: 901410..901856 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPDSF_RS04175	896704..897369	+	666	WP_002210975.1	phage shock protein PspA	-
YPDSF_RS04180	897531..897758	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPDSF_RS04185	897758..898117	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPDSF_RS04190	898202..898444	+	243	WP_002216375.1	phage shock protein PspD	-
YPDSF_RS04195	898425..899822	+	1398	WP_011906190.1	YcjX family protein	-
YPDSF_RS04200	899819..900880	+	1062	WP_002210980.1	YcjF family protein	-
YPDSF_RS04205	900890..901348	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
YPDSF_RS04210	901410..901856	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
YPDSF_RS04215	902192..903769	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
YPDSF_RS04220	903916..904374	-	459	WP_002213759.1	IS200/IS605-like element IS1541A family transposase	-
YPDSF_RS04225	904523..905305	-	783	WP_001317493.1	IS21-like element IS100kyp family helper ATPase IstB	-
YPDSF_RS04230	905302..906324	-	1023	WP_011901829.1	IS21-like element IS100 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T22022 WP_002210981.1 NC_009381:c901348-900890 [Yersinia pestis Pestoides F]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T22022 NC_009381:c901348-900890 [Yersinia pestis Pestoides F]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT22022 WP_002210982.1 NC_009381:c901856-901410 [Yersinia pestis Pestoides F]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT22022 NC_009381:c901856-901410 [Yersinia pestis Pestoides F]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1