220215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 130471..130993 Replicon plasmid pKP18-2110-2-1
Accession NZ_CP084987
Organism Klebsiella pneumoniae strain KP18-2110-2

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag LH404_RS26860 Protein ID WP_004181778.1
Coordinates 130471..130755 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag LH404_RS26865 Protein ID WP_004181777.1
Coordinates 130745..130993 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH404_RS26835 127938..128216 - 279 WP_044349308.1 hypothetical protein -
LH404_RS26840 129015..129302 - 288 WP_044349311.1 helix-turn-helix transcriptional regulator -
LH404_RS26845 129307..129738 - 432 WP_044349313.1 hypothetical protein -
LH404_RS26850 129782..129964 - 183 WP_044349315.1 type II toxin-antitoxin system HicA family toxin -
LH404_RS26855 130079..130450 + 372 WP_223884736.1 type II toxin-antitoxin system PrlF family antitoxin -
LH404_RS26860 130471..130755 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH404_RS26865 130745..130993 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LH404_RS26870 131285..133084 + 1800 WP_064371185.1 ATP-dependent helicase -
LH404_RS26875 133413..134417 + 1005 WP_064371184.1 hypothetical protein -
LH404_RS26880 134553..134906 + 354 WP_042927270.1 hypothetical protein -
LH404_RS26885 134966..135823 + 858 WP_064371183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ARR-3 / dfrA27 / aadA16 / qacE / sul1 / blaNDM-1 / mph(A) / aac(3)-IId / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 katA 1..362034 362034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T220215 WP_004181778.1 NZ_CP084987:c130755-130471 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T220215 NZ_CP116981:c3523748-3523413 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT220215 WP_004181777.1 NZ_CP084987:c130993-130745 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT220215 NZ_CP116981:c3523996-3523748 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References