220212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4772233..4772749 Replicon chromosome
Accession NZ_CP084986
Organism Klebsiella pneumoniae strain KP18-2110-2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag LH404_RS23480 Protein ID WP_002886902.1
Coordinates 4772233..4772517 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag LH404_RS23485 Protein ID WP_002886901.1
Coordinates 4772507..4772749 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH404_RS23455 4767717..4767980 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LH404_RS23460 4768110..4768283 + 174 WP_002886906.1 hypothetical protein -
LH404_RS23465 4768286..4769029 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LH404_RS23470 4769386..4771524 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
LH404_RS23475 4771765..4772229 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LH404_RS23480 4772233..4772517 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH404_RS23485 4772507..4772749 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LH404_RS23490 4772827..4774737 - 1911 WP_004152270.1 PRD domain-containing protein -
LH404_RS23495 4774760..4775914 - 1155 WP_002886900.1 lactonase family protein -
LH404_RS23500 4775980..4776720 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T220212 WP_002886902.1 NZ_CP084986:c4772517-4772233 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T220212 NZ_CP116981:c2740482-2740228 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATATCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT220212 WP_002886901.1 NZ_CP084986:c4772749-4772507 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT220212 NZ_CP116981:c2740730-2740479 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References