Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 698208..698880 Replicon chromosome
Accession NC_009381
Organism Yersinia pestis Pestoides F

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag YPDSF_RS03215 Protein ID WP_002215144.1
Coordinates 698455..698880 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag YPDSF_RS03210 Protein ID WP_002209939.1
Coordinates 698208..698474 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPDSF_RS03190 694065..695168 + 1104 WP_002209943.1 hypothetical protein -
YPDSF_RS03195 695370..696071 + 702 WP_002209942.1 hemolysin III family protein -
YPDSF_RS03200 696329..696826 + 498 WP_002209941.1 DUF2165 family protein -
YPDSF_RS03205 696899..697891 - 993 WP_002209940.1 tRNA-modifying protein YgfZ -
YPDSF_RS03210 698208..698474 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
YPDSF_RS03215 698455..698880 + 426 WP_002215144.1 protein YgfX Toxin
YPDSF_RS03220 698880..699578 + 699 WP_002209937.1 two-component system response regulator CreB -
YPDSF_RS03225 699603..701021 + 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
YPDSF_RS03230 701142..702599 + 1458 WP_002220113.1 cell envelope integrity protein CreD -
YPDSF_RS03235 702689..703207 - 519 WP_002209934.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T22020 WP_002215144.1 NC_009381:698455-698880 [Yersinia pestis Pestoides F]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T22020 NC_009381:698455-698880 [Yersinia pestis Pestoides F]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT22020 WP_002209939.1 NC_009381:698208-698474 [Yersinia pestis Pestoides F]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT22020 NC_009381:698208-698474 [Yersinia pestis Pestoides F]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References