Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 299770..300292 Replicon plasmid pPAPIvir
Accession NZ_CP084985
Organism Klebsiella pneumoniae strain KP-PA

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag KYT91_RS27910 Protein ID WP_004181778.1
Coordinates 300008..300292 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag KYT91_RS27905 Protein ID WP_025368601.1
Coordinates 299770..300018 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYT91_RS27885 294979..295815 - 837 WP_223686625.1 hypothetical protein -
KYT91_RS27890 (KYT91_1520) 295862..296215 - 354 WP_004181774.1 hypothetical protein -
KYT91_RS27895 (KYT91_1525) 296360..297346 - 987 WP_025368599.1 hypothetical protein -
KYT91_RS27900 (KYT91_1530) 297680..299479 - 1800 WP_025368600.1 ATP-dependent helicase -
KYT91_RS27905 (KYT91_1535) 299770..300018 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KYT91_RS27910 (KYT91_1540) 300008..300292 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYT91_RS27915 (KYT91_1545) 300522..301748 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
KYT91_RS27920 (KYT91_1550) 302034..302459 - 426 WP_040120489.1 IS200/IS605 family transposase -
KYT91_RS27925 (KYT91_1555) 302496..303722 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
KYT91_RS27930 303788..304914 - 1127 Protein_329 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aac(6')-Ib / ant(3'')-Ia / blaOXA-9 / blaTEM-1A / aph(3')-Ia / mph(A) / sul1 / qacE / dfrA5 / mph(E) / msr(E) / armA / sul2 / blaCTX-M-15 rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..382377 382377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T220196 WP_004181778.1 NZ_CP084985:300008-300292 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T220196 NZ_CP116977:51236-51388 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT220196 WP_025368601.1 NZ_CP084985:299770-300018 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT220196 NZ_CP116977:c51181-51124 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References