Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4805628..4806144 Replicon chromosome
Accession NZ_CP084984
Organism Klebsiella pneumoniae strain KP-PA

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag KYT91_RS23540 Protein ID WP_009486548.1
Coordinates 4805628..4805912 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KYT91_RS23545 Protein ID WP_002886901.1
Coordinates 4805902..4806144 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYT91_RS23515 (4801045) 4801045..4801308 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KYT91_RS23520 (4801438) 4801438..4801611 + 174 WP_032433782.1 hypothetical protein -
KYT91_RS23525 (4801614) 4801614..4802357 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KYT91_RS23530 (4802714) 4802714..4804852 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KYT91_RS23535 (4805160) 4805160..4805624 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KYT91_RS23540 (4805628) 4805628..4805912 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KYT91_RS23545 (4805902) 4805902..4806144 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KYT91_RS23550 (4806222) 4806222..4808132 - 1911 WP_009486549.1 PRD domain-containing protein -
KYT91_RS23555 (4808155) 4808155..4809309 - 1155 WP_002886900.1 lactonase family protein -
KYT91_RS23560 (4809376) 4809376..4810116 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T220191 WP_009486548.1 NZ_CP084984:c4805912-4805628 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T220191 NZ_CP116976:c3974117-3973839 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT220191 WP_002886901.1 NZ_CP084984:c4806144-4805902 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT220191 NZ_CP116976:c3974380-3974120 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References