Detailed information of TA system TA022018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1107318..1107853
• Replicon: chromosome
• Accession: NC_009380
• Organism: Salinispora tropica CNB-440

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: STROP_RS05005
• Protein ID: WP_018829754.1
• Coordinates: 1107318..1107572 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A4X3L4
• Locus tag: STROP_RS05010
• Protein ID: WP_011904898.1
• Coordinates: 1107569..1107853 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STROP_RS04980	1103192..1103671	+	480	WP_011904893.1	SsrA-binding protein SmpB	-
STROP_RS04985	1104237..1105178	+	942	WP_011904894.1	hypothetical protein	-
STROP_RS04990	1105203..1106006	-	804	WP_011904895.1	S-methyl-5'-thioadenosine phosphorylase	-
STROP_RS04995	1106139..1106738	+	600	WP_018829770.1	YqgE/AlgH family protein	-
STROP_RS05005	1107318..1107572	-	255	WP_018829754.1	Txe/YoeB family addiction module toxin	Toxin
STROP_RS05010	1107569..1107853	-	285	WP_011904898.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
STROP_RS05015	1108114..1108875	-	762	WP_028564065.1	alpha/beta hydrolase	-
STROP_RS05020	1109004..1109681	-	678	WP_011904900.1	class I SAM-dependent methyltransferase	-
STROP_RS05025	1109774..1110556	-	783	WP_011904901.1	DUF4239 domain-containing protein	-
STROP_RS05030	1110807..1111010	-	204	WP_011904902.1	DUF397 domain-containing protein	-
STROP_RS23645	1111007..1111201	-	195	Protein_1006	transcriptional regulator	-
STROP_RS05035	1111234..1112397	-	1164	WP_043535206.1	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10287.62 Da
• Isoelectric Point: 9.9829

>T22018 WP_018829754.1 NC_009380:c1107572-1107318 [Salinispora tropica CNB-440]
VKVQFAGRGWEDYLTWQRDRQMLRRVNALIEDIRRNGHQGIGKPEQLRGNWAGFWSRRIDQEHRLVYRIMDDTVQIAQCR
YHYE

Nucleotide

• Length: 255 bp

>T22018 NC_009380:c1107572-1107318 [Salinispora tropica CNB-440]
GTGAAGGTCCAGTTCGCCGGCCGAGGCTGGGAGGACTATCTGACCTGGCAACGAGATCGCCAGATGCTCAGACGAGTGAA
CGCCTTGATCGAGGACATCCGCCGCAACGGCCACCAAGGCATCGGCAAACCGGAGCAGCTCCGTGGAAACTGGGCGGGAT
TCTGGTCGAGACGCATCGACCAGGAACACCGCCTCGTATACCGGATCATGGACGACACGGTGCAGATCGCGCAGTGCCGC
TATCACTACGAATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10186.31 Da
• Isoelectric Point: 4.4280

>AT22018 WP_011904898.1 NC_009380:c1107853-1107569 [Salinispora tropica CNB-440]
MRTVPYSEVRQNLAKMLDHVVDDAEEVVVTRSGREAAVIISLREYESLKETAYLMASPANARRLNEAVEELRNGGGETHD
LIDPDASSGAASAA

Nucleotide

• Length: 285 bp

>AT22018 NC_009380:c1107853-1107569 [Salinispora tropica CNB-440]
ATGCGCACCGTTCCCTACTCAGAAGTCCGGCAGAACCTGGCCAAGATGCTCGACCATGTCGTGGACGACGCCGAGGAGGT
GGTGGTCACCCGCTCCGGCCGGGAGGCCGCGGTCATCATCTCGCTGCGCGAGTACGAGTCGTTGAAGGAGACGGCCTACC
TGATGGCCAGCCCCGCCAACGCGCGCCGTCTGAATGAGGCCGTCGAAGAGCTGCGTAACGGGGGTGGGGAGACGCACGAC
CTGATCGACCCCGACGCCAGTTCAGGCGCGGCGTCGGCGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A4X3L4