Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1451900..1452543 Replicon chromosome
Accession NZ_CP084984
Organism Klebsiella pneumoniae strain KP-PA

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag KYT91_RS07235 Protein ID WP_032433387.1
Coordinates 1452127..1452543 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag KYT91_RS07230 Protein ID WP_001261276.1
Coordinates 1451900..1452130 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KYT91_RS07215 (1446922) 1446922..1448009 + 1088 Protein_1415 transcriptional regulator -
KYT91_RS07220 (1448012) 1448012..1450252 + 2241 WP_045326788.1 P-loop NTPase fold protein -
KYT91_RS07225 (1450780) 1450780..1451595 - 816 WP_032433388.1 hypothetical protein -
KYT91_RS07230 (1451900) 1451900..1452130 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KYT91_RS07235 (1452127) 1452127..1452543 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
KYT91_RS07240 (1452699) 1452699..1453679 + 981 WP_032433385.1 hypothetical protein -
KYT91_RS07245 (1453874) 1453874..1455445 - 1572 WP_032433383.1 AAA family ATPase -
KYT91_RS07250 (1455764) 1455764..1456012 + 249 WP_032433382.1 hypothetical protein -
KYT91_RS07255 (1456071) 1456071..1456589 + 519 WP_045326794.1 hypothetical protein -
KYT91_RS07260 (1456620) 1456620..1457111 + 492 WP_032433378.1 hypothetical protein -
KYT91_RS07265 (1457171) 1457171..1457374 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1438751..1483618 44867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T220178 WP_032433387.1 NZ_CP084984:1452127-1452543 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T220178 NZ_CP116976:c1042992-1042889 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT220178 WP_001261276.1 NZ_CP084984:1451900-1452130 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT220178 NZ_CP116976:1042873-1043122 [Escherichia coli]
CTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTG
CGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
TGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCG
GTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References