Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 30727..31288 Replicon plasmid pDSM110277_d
Accession NZ_CP084963
Organism Sulfitobacter pontiacus strain DSM 110277

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DSM110277_RS18050 Protein ID WP_243252184.1
Coordinates 31013..31288 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1N7QLX2
Locus tag DSM110277_RS18045 Protein ID WP_044353023.1
Coordinates 30727..31026 (+) Length 100 a.a.

Genomic Context

DSM110277_RS18020DSM110277_RS18025DSM110277_RS18030DSM110277_RS18035DSM110277_RS18040DSM110277_RS18045DSM110277_RS18050DSM110277_RS18055DSM110277_RS18060
Location: 26468..26677 (210 bp)
Type: Others
Protein ID: WP_243252181.1
Location: 26766..27155 (390 bp)
Type: Others
Protein ID: WP_243252182.1
Location: 27312..29294 (1983 bp)
Type: Others
Protein ID: WP_243252183.1
Location: 29373..29966 (594 bp)
Type: Others
Protein ID: WP_132998379.1
Location: 29966..30622 (657 bp)
Type: Others
Protein ID: WP_132998378.1
Location: 30727..31026 (300 bp)
Type: Antitoxin
Protein ID: WP_044353023.1
Location: 31013..31288 (276 bp)
Type: Toxin
Protein ID: WP_243252184.1
Location: 31395..35657 (4263 bp)
Type: Others
Protein ID: WP_243252185.1
Location: 35779..36165 (387 bp)
Type: Others
Protein ID: WP_132998375.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DSM110277_RS18020 (DSM110277_03622)26468..26677+210WP_243252181.1DUF6330 family protein-
DSM110277_RS18025 (DSM110277_03623)26766..27155+390WP_243252182.1DUF3768 domain-containing protein-
DSM110277_RS18030 (DSM110277_03624)27312..29294+1983WP_243252183.1ParB/RepB/Spo0J family partition protein-
DSM110277_RS18035 (DSM110277_03625)29373..29966+594WP_132998379.1regulator-
DSM110277_RS18040 (DSM110277_03626)29966..30622+657WP_132998378.1hypothetical protein-
DSM110277_RS18045 (DSM110277_03627)30727..31026+300WP_044353023.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
DSM110277_RS18050 (DSM110277_03628)31013..31288+276WP_243252184.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DSM110277_RS18055 (DSM110277_03629)31395..35657+4263WP_243252185.1strawberry notch family protein-
DSM110277_RS18060 (DSM110277_03630)35779..36165+387WP_132998375.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..128813128813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10447.99 Da        Isoelectric Point: 4.7914

>T220173 WP_243252184.1 NZ_CP084963:31013-31288 [Sulfitobacter pontiacus]
MRNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Download         Length: 276 bp

>T220173 NZ_CP116975:c53331-53050 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10462.91 Da        Isoelectric Point: 5.6448

>AT220173 WP_044353023.1 NZ_CP084963:30727-31026 [Sulfitobacter pontiacus]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Download         Length: 300 bp

>AT220173 NZ_CP116975:c53572-53321 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1N7QLX2

References