Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 83510..84035 Replicon plasmid pCEP14_03
Accession NZ_CP084924
Organism Acinetobacter pittii strain CEP14

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LG653_RS20265 Protein ID WP_065996230.1
Coordinates 83510..83797 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LG653_RS20270 Protein ID WP_005130375.1
Coordinates 83787..84035 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG653_RS20235 (LG653_20235) 78722..79510 + 789 WP_068558565.1 OmpA family protein -
LG653_RS20240 (LG653_20240) 79756..80586 - 831 Protein_64 IS3 family transposase -
LG653_RS20245 (LG653_20245) 80870..81604 + 735 WP_071211297.1 hypothetical protein -
LG653_RS20250 (LG653_20250) 81635..81967 + 333 WP_005253224.1 hypothetical protein -
LG653_RS20255 (LG653_20255) 82142..82707 - 566 Protein_67 recombinase family protein -
LG653_RS20260 (LG653_20260) 83200..83349 + 150 WP_079878061.1 DUF4113 domain-containing protein -
LG653_RS20265 (LG653_20265) 83510..83797 - 288 WP_065996230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG653_RS20270 (LG653_20270) 83787..84035 - 249 WP_005130375.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LG653_RS20275 (LG653_20275) 84038..84463 - 426 WP_065996232.1 hypothetical protein -
LG653_RS20280 (LG653_20280) 84546..84614 - 69 Protein_72 helix-turn-helix domain-containing protein -
LG653_RS20285 (LG653_20285) 84730..84969 - 240 WP_005130377.1 hypothetical protein -
LG653_RS20290 (LG653_20290) 84966..85595 - 630 WP_005130378.1 AAA family ATPase -
LG653_RS20295 (LG653_20295) 86024..86938 + 915 WP_004843977.1 replication initiation protein RepM -
LG653_RS20300 (LG653_20300) 87528..88571 + 1044 WP_226789445.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..89672 89672
- flank IS/Tn - - 79756..80610 854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11160.07 Da        Isoelectric Point: 10.3011

>T220171 WP_065996230.1 NZ_CP084924:c83797-83510 [Acinetobacter pittii]
MTYKLDFLEEALAEWKKLNPSIKQPLKKKLIKVLENPRIPKNKLPGHPNRYKIKLRSVGYRLVYEVIDDEVIFIVIAVGR
RENNAVYDEANSRHS

Download         Length: 288 bp

>T220171 NZ_CP116972:55544-55696 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9258.77 Da        Isoelectric Point: 5.0491

>AT220171 WP_005130375.1 NZ_CP084924:c84035-83787 [Acinetobacter pittii]
MTQLIHARMTASITELKKSPMDTVLAGKGEPVAILNRNIPAFYCVPADLYETMMEQLEDLELNKIADARANQKRIRVNID
DL

Download         Length: 249 bp

>AT220171 NZ_CP116972:c55494-55432 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References