Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 950166..950790 Replicon chromosome
Accession NC_009376
Organism Pyrobaculum arsenaticum DSM 13514

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PARS_RS05380 Protein ID WP_011900550.1
Coordinates 950166..950573 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PARS_RS05385 Protein ID WP_011900551.1
Coordinates 950557..950790 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PARS_RS05360 (Pars_1061) 946226..946945 + 720 WP_011900546.1 ABC transporter ATP-binding protein -
PARS_RS05365 (Pars_1062) 947136..947465 - 330 WP_011900547.1 hypothetical protein -
PARS_RS05370 (Pars_1063) 948030..948878 + 849 WP_011900548.1 hypothetical protein -
PARS_RS05375 (Pars_1064) 948871..949965 + 1095 WP_011900549.1 AmmeMemoRadiSam system radical SAM enzyme -
PARS_RS05380 (Pars_1065) 950166..950573 - 408 WP_011900550.1 type II toxin-antitoxin system VapC family toxin Toxin
PARS_RS05385 (Pars_1066) 950557..950790 - 234 WP_011900551.1 hypothetical protein Antitoxin
PARS_RS05390 (Pars_1067) 951132..951458 - 327 WP_011900552.1 nucleotidyltransferase domain-containing protein -
PARS_RS05395 (Pars_1068) 951436..951855 - 420 WP_011900553.1 HEPN domain-containing protein -
PARS_RS05400 (Pars_1069) 952422..953558 + 1137 WP_128622226.1 Nre family DNA repair protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(4-125)

Antitoxin

Putative antitoxin VapB3-like

(2-74)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14995.35 Da        Isoelectric Point: 5.6570

>T22016 WP_011900550.1 NC_009376:c950573-950166 [Pyrobaculum arsenaticum DSM 13514]
MRLVVDASAIAALYLPEEGSEQVEKALSQARSLHTLDLAAYEAANVVWKHTRRGLLRQEEAAELVEEVLRLLKTLEVHTY
AEVLEDALRLALRHGITVYDAAYAALAEKIGGKLLTLDKQLAEKLPIALTPDRLR

Download         Length: 408 bp

>T22016 NC_009376:c950573-950166 [Pyrobaculum arsenaticum DSM 13514]
ATGCGGCTAGTCGTTGACGCCTCTGCTATAGCCGCATTGTATCTACCTGAGGAGGGGAGCGAGCAGGTGGAAAAAGCGCT
GAGCCAAGCCAGATCTCTACATACCCTCGACCTAGCCGCCTACGAGGCCGCCAACGTCGTGTGGAAGCATACTAGGCGCG
GGCTCCTCCGGCAAGAAGAAGCGGCTGAGCTGGTGGAGGAGGTGTTGCGGCTCCTCAAGACCTTGGAGGTGCACACCTAC
GCAGAGGTGCTGGAGGACGCCCTCCGCCTAGCGCTTAGACACGGCATCACGGTCTACGACGCCGCCTACGCGGCCCTAGC
CGAAAAGATAGGAGGGAAGTTGCTCACCCTAGATAAGCAATTAGCTGAAAAACTCCCAATAGCATTAACCCCGGATCGTC
TGCGATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9073.34 Da        Isoelectric Point: 8.7348

>AT22016 WP_011900551.1 NC_009376:c950790-950557 [Pyrobaculum arsenaticum DSM 13514]
VSEVISVRVRKGLKEELEELGIDYAEAIRRFLEELVAVERRRRALERARELRERLSVRGHFPTSVDLIREDRDAASR

Download         Length: 234 bp

>AT22016 NC_009376:c950790-950557 [Pyrobaculum arsenaticum DSM 13514]
GTGAGCGAGGTGATCTCGGTTAGGGTGAGGAAGGGGCTTAAGGAGGAGCTTGAGGAGCTCGGCATAGACTACGCAGAAGC
TATCAGAAGGTTTCTGGAAGAGCTTGTAGCTGTGGAGAGGAGGAGGCGTGCCTTGGAGAGGGCCAGGGAGTTGAGGGAAA
GGCTTAGCGTGAGGGGGCATTTCCCTACCAGCGTTGACCTCATAAGAGAGGATAGAGATGCGGCTAGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References