Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 10043..10571 | Replicon | plasmid pCEP14_01 |
| Accession | NZ_CP084922 | ||
| Organism | Acinetobacter pittii strain CEP14 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B0V430 |
| Locus tag | LG653_RS19150 | Protein ID | WP_000221360.1 |
| Coordinates | 10278..10571 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B0V429 |
| Locus tag | LG653_RS19145 | Protein ID | WP_000246757.1 |
| Coordinates | 10043..10288 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LG653_RS19110 (LG653_19110) | 5445..6443 | + | 999 | WP_002120211.1 | zinc-binding alcohol dehydrogenase family protein | - |
| LG653_RS19115 (LG653_19115) | 6464..6748 | + | 285 | WP_000155817.1 | putative quinol monooxygenase | - |
| LG653_RS19120 (LG653_19120) | 6883..7104 | + | 222 | Protein_8 | IS3 family transposase | - |
| LG653_RS19125 (LG653_19125) | 7108..7197 | + | 90 | Protein_9 | DNA-binding protein | - |
| LG653_RS19130 (LG653_19130) | 7514..8032 | + | 519 | WP_000447196.1 | tetratricopeptide repeat protein | - |
| LG653_RS19135 (LG653_19135) | 8164..8676 | + | 513 | WP_001089570.1 | SMI1/KNR4 family protein | - |
| LG653_RS19140 (LG653_19140) | 8884..9786 | + | 903 | WP_000466974.1 | hypothetical protein | - |
| LG653_RS19145 (LG653_19145) | 10043..10288 | + | 246 | WP_000246757.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LG653_RS19150 (LG653_19150) | 10278..10571 | + | 294 | WP_000221360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LG653_RS19155 (LG653_19155) | 10758..10874 | + | 117 | Protein_15 | IS5/IS1182 family transposase | - |
| LG653_RS19160 (LG653_19160) | 11889..12197 | + | 309 | WP_000269910.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LG653_RS19165 (LG653_19165) | 12238..12540 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | - |
| LG653_RS19170 (LG653_19170) | 12533..12742 | + | 210 | WP_000069470.1 | hypothetical protein | - |
| LG653_RS19175 (LG653_19175) | 12852..13079 | - | 228 | WP_000555567.1 | hypothetical protein | - |
| LG653_RS19180 (LG653_19180) | 13845..14148 | - | 304 | Protein_20 | XRE family transcriptional regulator | - |
| LG653_RS19185 (LG653_19185) | 14141..14497 | - | 357 | WP_000269908.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..95483 | 95483 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11317.49 Da Isoelectric Point: 10.4753
>T220158 WP_000221360.1 NZ_CP084922:10278-10571 [Acinetobacter pittii]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T220158 NZ_CP116970:c2771089-2770562 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9264.63 Da Isoelectric Point: 4.2821
>AT220158 WP_000246757.1 NZ_CP084922:10043-10288 [Acinetobacter pittii]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
Download Length: 246 bp
>AT220158 NZ_CP116970:c2771362-2771096 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829RR87 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A009MZ79 |