Detailed information of TA system TA220156

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1791798..1792477
• Replicon: chromosome
• Accession: NZ_CP084921
• Organism: Acinetobacter pittii strain CEP14

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: LG653_RS08720
• Protein ID: WP_000838146.1
• Coordinates: 1791798..1791980 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: LG653_RS08725
• Protein ID: WP_000966688.1
• Coordinates: 1792073..1792477 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LG653_RS08685 (LG653_08685)	1787022..1787426	+	405	WP_002121581.1	hypothetical protein	-
LG653_RS08690 (LG653_08690)	1787398..1787766	+	369	WP_000539743.1	hypothetical protein	-
LG653_RS08695 (LG653_08695)	1787768..1788166	+	399	WP_002121567.1	phage tail terminator-like protein	-
LG653_RS08700 (LG653_08700)	1788235..1788588	+	354	WP_002121621.1	hypothetical protein	-
LG653_RS08705 (LG653_08705)	1788588..1789916	+	1329	WP_023187966.1	hypothetical protein	-
LG653_RS08710 (LG653_08710)	1789969..1790886	+	918	WP_002121543.1	phage tail tube protein	-
LG653_RS08715 (LG653_08715)	1790957..1791472	+	516	WP_025464105.1	hypothetical protein	-
LG653_RS08720 (LG653_08720)	1791798..1791980	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
LG653_RS08725 (LG653_08725)	1792073..1792477	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LG653_RS08730 (LG653_08730)	1792576..1793256	+	681	WP_000721572.1	hypothetical protein	-
LG653_RS08735 (LG653_08735)	1793258..1793521	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1766573..1829115	62542

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T220156 WP_000838146.1 NZ_CP084921:1791798-1791980 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T220156 NZ_CP116970:c2199149-2198742 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT220156 WP_000966688.1 NZ_CP084921:1792073-1792477 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT220156 NZ_CP116970:c2199396-2199130 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTTGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6