Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 76394..77047 Replicon chromosome
Accession NZ_CP084921
Organism Acinetobacter pittii strain CEP14

Toxin (Protein)


Gene name cptA Uniprot ID A0A009NMD1
Locus tag LG653_RS00395 Protein ID WP_005804615.1
Coordinates 76394..76783 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag LG653_RS00400 Protein ID WP_002117064.1
Coordinates 76790..77047 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG653_RS00380 (LG653_00380) 71485..73695 - 2211 WP_005804618.1 TRAP transporter large permease subunit -
LG653_RS00385 (LG653_00385) 73875..74450 - 576 WP_025464189.1 rhombosortase -
LG653_RS00390 (LG653_00390) 74535..75623 - 1089 WP_005804616.1 hypothetical protein -
LG653_RS00395 (LG653_00395) 76394..76783 - 390 WP_005804615.1 hypothetical protein Toxin
LG653_RS00400 (LG653_00400) 76790..77047 - 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
LG653_RS00405 (LG653_00405) 77236..78408 + 1173 WP_025464188.1 acyl-CoA dehydrogenase family protein -
LG653_RS00410 (LG653_00410) 78459..79949 - 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
LG653_RS00415 (LG653_00415) 80131..80508 - 378 WP_002049717.1 50S ribosomal protein L17 -
LG653_RS00420 (LG653_00420) 80527..81534 - 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15553.65 Da        Isoelectric Point: 8.7390

>T220155 WP_005804615.1 NZ_CP084921:c76783-76394 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSIAYFSKKEI
YRGEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T220155 NZ_CP116970:c2070616-2070281 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT220155 WP_002117064.1 NZ_CP084921:c77047-76790 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT220155 NZ_CP116970:c2070864-2070616 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009NMD1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References