Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 3349917..3350482 Replicon chromosome
Accession NZ_CP084914
Organism Leptospira borgpetersenii strain MN900

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LH336_RS14825 Protein ID WP_011670965.1
Coordinates 3349917..3350240 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LH336_RS14830 Protein ID WP_011670966.1
Coordinates 3350234..3350482 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH336_RS14805 (LH336_14635) 3345124..3345867 - 744 WP_002728313.1 M15 family metallopeptidase -
LH336_RS14810 (LH336_14640) 3346201..3346545 + 345 WP_002728323.1 TIGR04452 family lipoprotein -
LH336_RS14815 (LH336_14645) 3346919..3347572 - 654 Protein_2922 helicase-related protein -
LH336_RS14820 (LH336_14650) 3347954..3349489 - 1536 WP_061208361.1 phosphomethylpyrimidine synthase ThiC -
LH336_RS14825 (LH336_14655) 3349917..3350240 - 324 WP_011670965.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LH336_RS14830 (LH336_14660) 3350234..3350482 - 249 WP_011670966.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LH336_RS14835 (LH336_14665) 3351160..3353340 - 2181 WP_193825543.1 ATP-dependent DNA helicase RecG -
LH336_RS14840 (LH336_14670) 3353321..3353737 - 417 WP_002725741.1 hypothetical protein -
LH336_RS14845 (LH336_14675) 3353734..3354411 - 678 WP_002725755.1 hypothetical protein -
LH336_RS14850 (LH336_14680) 3354414..3355415 - 1002 WP_002732926.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-104)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12296.80 Da        Isoelectric Point: 10.5161

>T220150 WP_011670965.1 NZ_CP084914:c3350240-3349917 [Leptospira borgpetersenii]
MVISQYEVYLINLDPTVGHEIKKSRPCVIISPNEMNKTIGTIIITPMTTKSRSYPTRVELTFQGKKGWIVLDQIRTVDKI
RLIKKLGKIDPKTVNKMKLIIKEMLVD

Download         Length: 324 bp

>T220150 NZ_CP116970:c741745-741569 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9444.97 Da        Isoelectric Point: 5.1749

>AT220150 WP_011670966.1 NZ_CP084914:c3350482-3350234 [Leptospira borgpetersenii]
MKALVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKSMSSNKDDKLLVPDSIDLSDKDW
EW

Download         Length: 249 bp

>AT220150 NZ_CP116970:c741523-741107 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGTGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References