Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 909021..909630 Replicon chromosome
Accession NC_009376
Organism Pyrobaculum arsenaticum DSM 13514

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PARS_RS05145 Protein ID WP_128622223.1
Coordinates 909021..909416 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PARS_RS05150 Protein ID WP_128622224.1
Coordinates 909406..909630 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PARS_RS05120 (Pars_1012) 904137..904382 + 246 WP_011900499.1 hypothetical protein -
PARS_RS05125 (Pars_1013) 904591..905466 + 876 WP_011900500.1 type II methionyl aminopeptidase -
PARS_RS05130 (Pars_1014) 905698..907077 - 1380 WP_128622222.1 phosphoenolpyruvate carboxylase -
PARS_RS05135 (Pars_1015) 907247..907591 + 345 WP_128867421.1 hypothetical protein -
PARS_RS05140 (Pars_1016) 907636..908799 - 1164 WP_128867422.1 pitrilysin family protein -
PARS_RS05145 (Pars_1017) 909021..909416 - 396 WP_128622223.1 type II toxin-antitoxin system VapC family toxin Toxin
PARS_RS05150 (Pars_1018) 909406..909630 - 225 WP_128622224.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PARS_RS13085 (Pars_1019) 910169..910297 + 129 WP_262373842.1 hypothetical protein -
PARS_RS05155 (Pars_1020) 910304..911149 - 846 WP_011900506.1 NAD+ synthase -
PARS_RS05160 (Pars_1021) 911146..911478 - 333 WP_011900507.1 P-II family nitrogen regulator -
PARS_RS05165 (Pars_1022) 911475..912722 - 1248 WP_011900508.1 ammonium transporter -
PARS_RS12400 913145..913291 + 147 WP_164905926.1 hypothetical protein -
PARS_RS05170 (Pars_1023) 913341..913544 + 204 WP_011900509.1 hypothetical protein -
PARS_RS12165 (Pars_1024) 913708..913878 + 171 WP_241428757.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

Post-segregation antitoxin CcdA

(5-47)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14733.14 Da        Isoelectric Point: 9.2206

>T22015 WP_128622223.1 NC_009376:c909416-909021 [Pyrobaculum arsenaticum DSM 13514]
MPVEYLVDASALYALVAHYDKWIRHRDRLAILHLTIYEAGNALWKEARLGRVDWAAAARHLKKVLSSLKVLDDPPLNEVL
GVAVKRGLTFYDASYAYVAESSGLVLVTQDQELLAKTRNAIDVVTFLKRLV

Download         Length: 396 bp

>T22015 NC_009376:c909416-909021 [Pyrobaculum arsenaticum DSM 13514]
ATGCCCGTTGAGTACTTGGTGGACGCGTCGGCGCTGTACGCCCTAGTGGCGCACTACGATAAGTGGATCAGGCATAGGGA
TAGGCTGGCTATCTTGCACTTGACTATATACGAGGCGGGCAACGCGTTGTGGAAAGAGGCGAGGCTGGGGAGGGTTGACT
GGGCCGCCGCGGCTAGGCATCTGAAAAAGGTGTTATCGAGCCTCAAGGTGTTGGACGACCCGCCGTTGAACGAGGTTTTG
GGGGTGGCGGTTAAGAGGGGGTTGACCTTCTACGACGCGAGCTACGCCTACGTGGCGGAGTCCTCCGGACTGGTTCTAGT
GACTCAGGATCAGGAGCTGTTGGCTAAGACTAGAAACGCCATAGACGTCGTGACCTTCTTAAAGAGGCTTGTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8728.98 Da        Isoelectric Point: 6.4436

>AT22015 WP_128622224.1 NC_009376:c909630-909406 [Pyrobaculum arsenaticum DSM 13514]
MSAVISVRVKRELKERARQLGINIREVVERALEEEIKRREEEELAKSLEELKRALSGISEREWVEAVREARDAR

Download         Length: 225 bp

>AT22015 NC_009376:c909630-909406 [Pyrobaculum arsenaticum DSM 13514]
ATGTCTGCGGTGATCAGCGTGAGGGTGAAGAGGGAGTTGAAGGAGAGGGCCAGGCAGCTGGGTATTAATATTAGGGAGGT
TGTGGAGAGGGCGCTGGAGGAGGAGATCAAGAGGCGCGAAGAGGAGGAGCTGGCCAAGTCGCTTGAGGAGCTGAAGAGGG
CGCTGTCGGGCATCTCCGAGAGGGAGTGGGTGGAGGCGGTGAGGGAGGCGCGGGATGCCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References