Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2225555..2226120 Replicon chromosome
Accession NZ_CP084910
Organism Asticcacaulis sp. AND118

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LH365_RS10715 Protein ID WP_226743624.1
Coordinates 2225555..2225833 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LH365_RS10720 Protein ID WP_226743625.1
Coordinates 2225830..2226120 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH365_RS10685 (LH365_10685) 2221101..2221514 - 414 WP_255606586.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
LH365_RS10690 (LH365_10690) 2221511..2221756 - 246 WP_226743619.1 hypothetical protein -
LH365_RS10695 (LH365_10695) 2221777..2222775 - 999 WP_226743620.1 ketol-acid reductoisomerase -
LH365_RS10700 (LH365_10700) 2222834..2223640 + 807 WP_226743621.1 thymidylate synthase -
LH365_RS10705 (LH365_10705) 2223823..2224341 + 519 WP_226743622.1 dihydrofolate reductase -
LH365_RS10710 (LH365_10710) 2224393..2225484 - 1092 WP_226743623.1 NADH:flavin oxidoreductase -
LH365_RS10715 (LH365_10715) 2225555..2225833 - 279 WP_226743624.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH365_RS10720 (LH365_10720) 2225830..2226120 - 291 WP_226743625.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LH365_RS10725 (LH365_10725) 2226180..2227280 - 1101 WP_226743626.1 Mrp/NBP35 family ATP-binding protein -
LH365_RS10730 (LH365_10730) 2227352..2228224 + 873 WP_226743627.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
LH365_RS10735 (LH365_10735) 2228469..2229620 + 1152 WP_226743628.1 aldose epimerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10548.05 Da        Isoelectric Point: 5.6643

>T220148 WP_226743624.1 NZ_CP084910:c2225833-2225555 [Asticcacaulis sp. AND118]
MMIQWSARALNDRIQTFQFIAQDSVAAAVRVDEAVEAAAEHLIDFPDSGRPGRARRTREWVLNGLPYLLIYTVEGDAIVI
WRVLHTSRLWPE

Download         Length: 279 bp

>T220148 NZ_CP116970:323476-323579 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10424.02 Da        Isoelectric Point: 8.6819

>AT220148 WP_226743625.1 NZ_CP084910:c2226120-2225830 [Asticcacaulis sp. AND118]
MAASEVVQARIDRAIKERAGAVLSQMGLTVSDAVRILLTRIANEGTLPAGLTVDPETYDAWLRAKVQEAMNDPRPLVSHD
EAKARMAALRADALRK

Download         Length: 291 bp

>AT220148 NZ_CP116970:c323617-323346 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References