Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 778571..779093 Replicon chromosome
Accession NZ_CP084910
Organism Asticcacaulis sp. AND118

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LH365_RS03695 Protein ID WP_226744856.1
Coordinates 778806..779093 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LH365_RS03690 Protein ID WP_226744855.1
Coordinates 778571..778813 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH365_RS03665 (LH365_03665) 773941..774624 - 684 WP_226744850.1 uroporphyrinogen-III synthase -
LH365_RS03670 (LH365_03670) 774735..775679 - 945 WP_226744851.1 hydroxymethylbilane synthase -
LH365_RS03675 (LH365_03675) 776028..777161 + 1134 WP_226744852.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
LH365_RS03680 (LH365_03680) 777158..778174 + 1017 WP_226744853.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
LH365_RS03685 (LH365_03685) 778202..778531 + 330 WP_226744854.1 Rieske 2Fe-2S domain-containing protein -
LH365_RS03690 (LH365_03690) 778571..778813 + 243 WP_226744855.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LH365_RS03695 (LH365_03695) 778806..779093 + 288 WP_226744856.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LH365_RS03700 (LH365_03700) 779105..779851 - 747 WP_226744857.1 creatininase family protein -
LH365_RS03705 (LH365_03705) 780014..781960 + 1947 WP_226744858.1 acetate--CoA ligase -
LH365_RS03710 (LH365_03710) 782001..782450 - 450 WP_226744859.1 hemerythrin domain-containing protein -
LH365_RS03715 (LH365_03715) 782548..783195 - 648 WP_226744860.1 DNA-3-methyladenine glycosylase 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 770918..779093 8175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11134.78 Da        Isoelectric Point: 9.6749

>T220147 WP_226744856.1 NZ_CP084910:778806-779093 [Asticcacaulis sp. AND118]
MAETYRLRPAARADLADIWRYSRTQWSVDQADRYTRLLMTAFDDLASGRRNGKPVVVRVGYLKYACGSHIIYYRLDNGLE
IVRVLHQRMDVEINL

Download         Length: 288 bp

>T220147 NZ_CP116965:12447-13310 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTACGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8810.85 Da        Isoelectric Point: 4.8377

>AT220147 WP_226744855.1 NZ_CP084910:778571-778813 [Asticcacaulis sp. AND118]
MTRTTSMSLGEHFTRFIATQVEEGRYGSASDVVRAGLRLLEEHEAKIKALQQALIEGEQSGVAEAFDGEAFLKEMRADHG

Download         Length: 243 bp

>AT220147 NZ_CP116965:12173-12445 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References