Detailed information of TA system TA220147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 778571..779093
• Replicon: chromosome
• Accession: NZ_CP084910
• Organism: Asticcacaulis sp. AND118

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LH365_RS03695
• Protein ID: WP_226744856.1
• Coordinates: 778806..779093 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: LH365_RS03690
• Protein ID: WP_226744855.1
• Coordinates: 778571..778813 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LH365_RS03665 (LH365_03665)	773941..774624	-	684	WP_226744850.1	uroporphyrinogen-III synthase	-
LH365_RS03670 (LH365_03670)	774735..775679	-	945	WP_226744851.1	hydroxymethylbilane synthase	-
LH365_RS03675 (LH365_03675)	776028..777161	+	1134	WP_226744852.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
LH365_RS03680 (LH365_03680)	777158..778174	+	1017	WP_226744853.1	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	-
LH365_RS03685 (LH365_03685)	778202..778531	+	330	WP_226744854.1	Rieske 2Fe-2S domain-containing protein	-
LH365_RS03690 (LH365_03690)	778571..778813	+	243	WP_226744855.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LH365_RS03695 (LH365_03695)	778806..779093	+	288	WP_226744856.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LH365_RS03700 (LH365_03700)	779105..779851	-	747	WP_226744857.1	creatininase family protein	-
LH365_RS03705 (LH365_03705)	780014..781960	+	1947	WP_226744858.1	acetate--CoA ligase	-
LH365_RS03710 (LH365_03710)	782001..782450	-	450	WP_226744859.1	hemerythrin domain-containing protein	-
LH365_RS03715 (LH365_03715)	782548..783195	-	648	WP_226744860.1	DNA-3-methyladenine glycosylase 2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	770918..779093	8175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11134.78 Da
• Isoelectric Point: 9.6749

>T220147 WP_226744856.1 NZ_CP084910:778806-779093 [Asticcacaulis sp. AND118]
MAETYRLRPAARADLADIWRYSRTQWSVDQADRYTRLLMTAFDDLASGRRNGKPVVVRVGYLKYACGSHIIYYRLDNGLE
IVRVLHQRMDVEINL

Nucleotide

• Length: 288 bp

>T220147 NZ_CP116965:12447-13310 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTACGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8810.85 Da
• Isoelectric Point: 4.8377

>AT220147 WP_226744855.1 NZ_CP084910:778571-778813 [Asticcacaulis sp. AND118]
MTRTTSMSLGEHFTRFIATQVEEGRYGSASDVVRAGLRLLEEHEAKIKALQQALIEGEQSGVAEAFDGEAFLKEMRADHG

Nucleotide

• Length: 243 bp

>AT220147 NZ_CP116965:12173-12445 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA