Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 103488..105047 Replicon plasmid 4
Accession NC_009349
Organism Aeromonas salmonicida subsp. salmonicida A449

Toxin (Protein)


Gene name hipA Uniprot ID A0A189PGV3
Locus tag ASA_RS22290 Protein ID WP_011899352.1
Coordinates 103488..104792 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A189PGR7
Locus tag ASA_RS22295 Protein ID WP_011899353.1
Coordinates 104796..105047 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASA_RS24485 100855..101250 + 396 Protein_103 IS21-like element ISAs29 family helper ATPase IstB -
ASA_RS22280 101330..101716 - 387 Protein_104 type VI secretion system effector Hcp1 -
ASA_RS24490 101991..102509 - 519 WP_139026991.1 hypothetical protein -
ASA_RS22285 102989..103483 - 495 WP_011899351.1 hypothetical protein -
ASA_RS22290 103488..104792 - 1305 WP_011899352.1 type II toxin-antitoxin system HipA family toxin Toxin
ASA_RS22295 104796..105047 - 252 WP_011899353.1 XRE family transcriptional regulator Antitoxin
ASA_RS22300 105292..106296 - 1005 WP_162096743.1 tyrosine-type recombinase/integrase -
ASA_RS22305 106299..106829 - 531 WP_011899355.1 hypothetical protein -
ASA_RS22310 107178..107819 + 642 WP_011899356.1 hypothetical protein -
ASA_RS24500 107831..108661 + 831 WP_139026989.1 hypothetical protein -
ASA_RS22315 109146..109694 + 549 WP_011899358.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(E) / sul1 / qacE / ant(3'')-Ia / cat vgrG1 / hcp 1..166749 166749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(7-67)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 48013.16 Da        Isoelectric Point: 6.6361

>T22013 WP_011899352.1 NC_009349:c104792-103488 [Aeromonas salmonicida subsp. salmonicida A449]
MRAQQLIVAMNGEVVGTLYRAGNGAMSFQYTPEWVAEPGSRPLSLSLPLGHSRIRGSEVFNFFSNLLPDSEAIIARMQAR
FHVETAHPFDLLASVGRDCVGAIQLYPPGIDIPPVTETLAEPLEDAQIEQLLEGYQVAPLGMAEDVDFRISIAGAQEKTA
LLWHQGRWQRPQGSTPTSHIFKLPIGRIVQNNIDLRDSCENEWLCLLIAKAFGFDVANADLAAFGQKRVLIVERFDRRWS
RNGEWLLRLPQEDFCQAMGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNYSIFIEP
ASSFRMTPIYDVMSAFPIFESGGIAAQKAKMAMALQGKNKQYHFAMIQPRHFISTAVHVGFSPDRAARLMHEMAADTESV
ISAVTAELPANFPEHISNAIFQGLSSQAAKIMRG

Download         Length: 1305 bp

>T22013 NC_009349:c104792-103488 [Aeromonas salmonicida subsp. salmonicida A449]
ATGAGAGCGCAGCAGCTGATAGTGGCAATGAACGGCGAGGTTGTGGGCACATTGTACCGAGCTGGCAACGGAGCCATGTC
ATTCCAATACACGCCTGAATGGGTCGCAGAACCAGGTTCTCGTCCGCTATCACTGTCACTACCTCTGGGCCATAGCCGGA
TCAGAGGAAGTGAAGTCTTCAATTTTTTTAGCAACCTTCTGCCCGACTCCGAGGCGATCATTGCTAGGATGCAGGCCCGG
TTCCACGTTGAGACAGCACACCCCTTTGATCTGTTGGCTAGTGTCGGCCGAGATTGTGTTGGCGCTATCCAGCTCTACCC
GCCCGGTATCGATATCCCTCCTGTCACGGAGACGCTTGCAGAGCCACTGGAAGACGCACAGATTGAGCAGTTGCTGGAAG
GCTATCAGGTGGCACCACTTGGTATGGCTGAGGATGTAGACTTTCGGATCTCGATTGCCGGTGCCCAAGAAAAGACGGCA
TTGCTTTGGCACCAAGGGCGCTGGCAGCGACCGCAGGGCAGCACCCCGACAAGTCATATCTTCAAGCTTCCCATCGGTCG
GATCGTACAAAACAACATCGACCTCCGAGACAGTTGCGAGAATGAATGGCTCTGCCTGCTGATCGCAAAGGCATTTGGCT
TTGACGTTGCCAATGCCGACTTGGCAGCATTTGGCCAAAAGCGTGTGCTGATCGTAGAGCGGTTCGATAGACGCTGGTCG
AGAAACGGTGAATGGTTGTTGAGGTTGCCTCAGGAAGATTTTTGCCAGGCGATGGGGATTGCCCCGGCTCTGAAATACGA
GTCCCATGGTGGCCCCGGCATTGCTGATGCTATGAAGTTGTTGTTGGGTTCCCGGCTAGCAGCCAAGGATAGAGAACAGT
TCTTCAAATCGCAGATCCTGTTCTGGATGTTGGCGGCGATCGATGGGCACGGAAAGAACTACAGCATCTTCATCGAGCCT
GCGTCGTCGTTCAGGATGACCCCCATCTATGATGTCATGTCAGCCTTTCCGATCTTCGAAAGCGGTGGCATTGCAGCTCA
AAAGGCCAAAATGGCGATGGCACTCCAAGGGAAAAATAAGCAGTACCACTTTGCAATGATACAGCCGCGTCACTTCATCA
GTACCGCTGTTCATGTGGGGTTTTCACCGGATAGAGCTGCTCGACTCATGCACGAGATGGCCGCTGACACCGAATCGGTG
ATCTCGGCTGTAACTGCTGAGTTGCCAGCCAATTTCCCTGAGCACATCAGCAATGCCATTTTCCAAGGGCTATCCAGCCA
GGCTGCAAAGATTATGAGGGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9290.61 Da        Isoelectric Point: 7.2047

>AT22013 WP_011899353.1 NC_009349:c105047-104796 [Aeromonas salmonicida subsp. salmonicida A449]
MKVTSPASLASAIRDHRKVSKLTQKDAAALVGIKQATVSDFENRPESTKLETLFKILAALDLELHVVKRGSTLDEEQAWD
REW

Download         Length: 252 bp

>AT22013 NC_009349:c105047-104796 [Aeromonas salmonicida subsp. salmonicida A449]
ATGAAGGTTACATCTCCAGCCTCTCTGGCTTCTGCTATTCGCGACCATCGCAAGGTCAGTAAACTGACGCAGAAAGATGC
TGCGGCATTGGTTGGGATTAAGCAGGCGACAGTCTCAGATTTTGAGAACCGGCCTGAGTCTACCAAGCTGGAGACGCTAT
TCAAGATCCTTGCTGCACTGGATCTGGAGCTTCATGTGGTTAAGCGGGGCTCTACCCTGGATGAGGAGCAAGCTTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A189PGV3

Antitoxin

Source ID Structure
AlphaFold DB A0A189PGR7

References